Evidence map›Paper›PMID 38956819›Full record

ArticleBrain and behavior2024

The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.

Zhimai Lyu, Guodong Xiao, Dingyi Xie, Dandan Huang, Yanjun Chen, Chunmei Wu, Yanwei Lai, Zitan Song, Lijuan Huang, Hui Ming and 4 more

Abstract read
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In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhimai LyuDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.ORCID 0000-0002-6698-7501
Guodong XiaoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Dingyi XieDepartment of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
Dandan HuangDepartment of Basic Medical Sciences, Gannan Medical University, Ganzhou, China.
Yanjun ChenDepartment of International Exchange and Cooperation, Jiangxi University of Chinese Medicine, Nanchang, China.
Chunmei WuDepartment of Health Statistics, School of Public Health & Health Management, Gannan Medical University, Ganzhou, China.
Yanwei LaiDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Zitan SongDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Lijuan HuangDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Hui MingDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Yichen JiangDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Jinwei WangDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Rixin ChenDepartment of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
Weifeng LuoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

Collaborative Innovation Center for Moxibustion Therapy Research and Clinical TranslationKey Laboratory of Noninvasive Neuromodulation of GanzhouMajor Science and Technology Research and Development Project of Jiangxi Province 20232ACG01006
6 · The paper itself

Abstract

backgroundHigh-frequency repeated transcranial magnetic stimulation (rTMS) stimulating the primary motor cortex (M1) is an alternative, adjunctive therapy for improving the motor symptoms of Parkinson's disease (PD). However, whether the high frequency of rTMS positively correlates to the improvement of motor symptoms of PD is still undecided. By controlling for other parameters, a disease animal model may be useful to compare the neuroprotective effects of different high frequencies of rTMS.

objectiveThe current exploratory study was designed to compare the protective effects of four common high frequencies of rTMS (5, 10, 15, and 20 Hz) and iTBS (a special form of high-frequency rTMS) and explore the optimal high-frequency rTMS on an animal PD model.

methodsFollowing high frequencies of rTMS application (twice a week for 5 weeks) in a MPTP/probenecid-induced chronic PD model, the effects of the five protocols on motor behavior as well as dopaminergic neuron degeneration levels were identified. The underlying molecular mechanisms were further explored.

resultsWe found that all the high frequencies of rTMS had protective effects on the motor functions of PD models to varying degrees. Among them, the 10, 15, and 20 Hz rTMS interventions induced comparable preservation of motor function through the protection of nigrostriatal dopamine neurons. The enhancement of brain-derived neurotrophic factor (BDNF), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT-2) and the suppression of TNF-α and IL-1β in the nigrostriatum were involved in the process. The efficacy of iTBS was inferior to that of the above three protocols. The effect of 5 Hz rTMS protocol was weakest.

conclusionsCombined with the results of the present study and the possible side effects induced by rTMS, we concluded that 10 Hz might be the optimal stimulation frequency for preserving the motor functions of PD models using rTMS treatment.

Indexed as

Disease Models, AnimalMice, Inbred C57BLParkinsonian DisordersProbenecidTranscranial Magnetic Stimulation1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain-Derived Neurotrophic FactorCorpus StriatumDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsInterleukin-1betaMaleMiceMotor ActivityMotor Cortex1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineBdnf protein, mouseBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsInterleukin-1betaProbenecidSlc18a2 protein, mouseVesicular Monoamine Transport Proteinsexcitatoryhigh frequencymotor functionsParkinson's diseaserepeated transcranial magnetic stimulation

Identifiers

PMID38956819
PMCPMC11219284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.