ArticleEuropean journal of medical research2024
Sex-related differences in left atrial substrate among patients with atrial fibrillation: evidence from high-density voltage mapping.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Sex-specific assumptions underlie cardiovascular digital twin technologies: A narrative review.PLOS digital health · 2026Review
- Sex differences in atrial fibrillation recurrence after catheter ablation: research status and progress.Biology of sex differences · 2026Review
- A computed tomography-based radiomics-clinical model incorporating left atrial and proximal pulmonary vein features predicts recurrence after radiofrequency catheter ablation of atrial fibrillation: a multicenter study.Frontiers in medicine · 2026Article
- Arrhythmia-Induced Cardiomyopathy in Atrial Fibrillation: Pathogenesis, Diagnosis, and Treatment.Life (Basel, Switzerland) · 2025Review
- Association of HARMSBMC cardiovascular disorders · 2025Observational
- Article
- Sex differences in atrial potential morphology.International journal of cardiology. Heart & vasculature · 2025Article
- The relative voltage index: a novel tailored method to identify left atrial low voltage areas in non-paroxysmal AF.Frontiers in cardiovascular medicine · 2025Article
- Inflammation and Nutritional Status Mediated the Increased of Risk of Atrial Fibrillation Recurrence Associated with eGFRdiff Post-Ablation.Journal of inflammation research · 2024Article
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7 authors.
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Abstract
backgroundThere is sufficient evidence that women with atrial fibrillation (AF) have a greater symptom burden than men with AF and are more likely to experience recurrence after catheter ablation. However, the mechanisms underlying these sex differences are unclear.
methodsWe prospectively enrolled 125 consecutive patients, including 40 non-AF patients and 85 AF patients, who underwent high-density voltage mapping during sinus rhythm and AF patients who underwent first ablation.
resultsOverall, 37 (44%) female patients with AF and 24 (60%) female non-AF patients with a mean age of 61.7 ± 11.6 years and 53.6 ± 16.7 years, respectively, were enrolled in this study. The results showed that the atrial voltage of female AF patients was significantly lower than that of male AF patients (1.11 ± 0.58 mV vs. 1.53 ± 0.65 mV; P = 0.003), while there were no significant sex differences in non-AF patients (3.02 ± 0.86 mV vs. 3.21 ± 0.84 mV; P = 0.498). Multiple linear regression analysis revealed that female sex (- 0.29, 95% confidence interval [CI] - 0.64 to - 0.13, P = 0.004) and AF type (- 0.32, 95% CI - 0.69 to - 0.13, P = 0.004) were the only factors independently associated with voltage. Compared with men, women in the paroxysmal AF group had a 3.5-fold greater incidence of recurrence (adjusted hazard ratio 4.49; 95% CI 1.101-18.332, P = 0.036). Both globally and regionally, the results showed that sex-related differences in voltage values occurred prominently in paroxysmal AF patients but not in nonparoxysmal AF patients.
conclusionSex-related differences in atrial substrates and arrhythmia-free survival were found in paroxysmal AF patients, suggesting the existence of sex-related pathophysiological factors.
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