Evidence map›Paper›PMID 38956597›Full record

ArticleBMC veterinary research2024

Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis.

Andreina de Carvalho Araujo, Andrew Yong Cho, Laura Morais Nascimento Silva, Thais Camilo Corrêa, Gabriela Cristini de Souza, Adriana Silva Albuquerque, Eduardo Macagnan, Cristiane K M Kolesnikvoas, Rafael Meurer, Jenyffer Vierheller Vieira and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Genomic detection of highly pathogenic avian influenza H5N1 in Antarctic seabirds reveals connectivity with South American viral lineages.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Andreina de Carvalho Araujo *Department of Veterinary Medicine, FZEA- USP, University of São Paulo, 225 Av Duque de Caxias Norte, Pirassununga, SP, 13635900, Brazil.
Andrew Yong Cho *Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea.
Laura Morais Nascimento Silva *Graduate Program in Experimental Epidemiology Applied to Zoonoses, Veterinary Medicine and Animal Science School, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Butantã, São Paulo, SP, 05508270, Brazil.
Thais Camilo CorrêaDepartment of Veterinary Medicine, FZEA- USP, University of São Paulo, 225 Av Duque de Caxias Norte, Pirassununga, SP, 13635900, Brazil.
Gabriela Cristini de SouzaZoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil.
Adriana Silva AlbuquerqueZoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil.
Eduardo MacagnanZoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil.
Cristiane K M KolesnikvoasR3 Animal Association, Rod. João Gualberto Soares 11.000, Florianópolis, SC, 88060-000, Brazil.
Rafael MeurerR3 Animal Association, Rod. João Gualberto Soares 11.000, Florianópolis, SC, 88060-000, Brazil.
Jenyffer Vierheller VieiraMarine Tetrapod Ecology and Conservation Laboratory, Marine Animal Stabilization Unit, São Francisco do Sul, University of the Joinville Region, UNIVILLE, Rod. Duque de Caxias 6.365, São Francisco do Sul, SC, 89240-000, Brazil.
Giulia Gaglianone LemosMarine Tetrapod Ecology and Conservation Laboratory, Marine Animal Stabilization Unit, São Francisco do Sul, University of the Joinville Region, UNIVILLE, Rod. Duque de Caxias 6.365, São Francisco do Sul, SC, 89240-000, Brazil.
André Silva BarretoLIBGeo, UNIVALI, Rua Uruguai 458, Itajaí, SC, 88301-902, Brazil.
Jeferson Luis DickMarine Animal Stabilization Unit, University of Vale do Itajaí - Univali BR, R Maria Emilia, 90, Armação, Penha, SC, 88385-000, Brazil.
Karina Rejane GrochAustralis Institute, Av. Atlantica, Sn, Praia de Itapirubá Norte, Imbituba, SC, 88780-000, Brazil.
Pedro Volkmer de CastilhoZoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil.
Deyvid AmgartenAlbert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil.
Fernanda MaltaAlbert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil.
Michael MillerBSL-3 Laboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas - UNICAMP, P.O.Box: 6109, Campinas, SP, 13083-862, Brazil.
Erick G DorlassAlbert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil.
Soledad PalametaBSL-3 Laboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas - UNICAMP, P.O.Box: 6109, Campinas, SP, 13083-862, Brazil.
Sun-Hak LeeAvian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea.
Clarice Weis ArnsBSL-3 Laboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas - UNICAMP, P.O.Box: 6109, Campinas, SP, 13083-862, Brazil.
Edison L DurigonBSL3+ Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1374, São Paulo, SP, 05508-000, Brazil.
João Renato R PinhoAlbert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil.
Dong-Hun LeeWildlife Health Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea.
Helena Lage FerreiraDepartment of Veterinary Medicine, FZEA- USP, University of São Paulo, 225 Av Duque de Caxias Norte, Pirassununga, SP, 13635900, Brazil. hlage@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts.

Indexed as

Influenza A Virus, H5N1 SubtypePhylogenySea LionsWhole Genome SequencingAnimalsBrazilGenetic VariationGenome, ViralGenotypeOrthomyxoviridae InfectionsHigh pathogenicity avian influenzaMarine mammalPublic healthSouth AmericaVirusWhole genome sequencing

Identifiers

PMID38956597
PMCPMC11221036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.