Evidence map›Paper›PMID 38956500›Full record

ArticleBMC genomics2024

Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp.

Roland Nathan Mandal, Jing Ke, Nusrat Hasan Kanika, Fuyan Wang, Jun Wang, Chenghui Wang

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Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Roland Nathan MandalKey Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Jing KeKey Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Nusrat Hasan KanikaKey Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Fuyan WangKey Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Jun WangKey Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China. wangjun@shou.edu.cn.
Chenghui WangKey Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China. wangch@shou.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeither a TYRP1-mediated highly conserved genetic network underlying skin color towards optimum defense nor the pathological tendency of its mutation is well understood. The Oujiang Color Common Carp (Cyprinus carpio var. color) as a model organism, offering valuable insights into genetics, coloration, aquaculture practices, and environmental health. Here, we performed a comparative skin transcriptome analysis on TYRP1 mutant and wild fishes by applying a conservative categorical approach considering different color phenotypes.

resultsOur results reveal that an unusual color phenotype may be sensitized with TYRP1 mutation as a result of upregulating several genes related to an anti-inflammatory autoimmune system in response to the COMT-mediated catecholamine neurotransmitters in the skin. Particularly, catecholamines-derived red/brown, red with blue colored membrane attack complex, and brown/grey colored reduced eumelanin are expected to be aggregated in the regenerated cells.

conclusionsIt is, thus, concluded that the regenerated cells with catecholamines, membrane attack complex, and eumelanin altogether may contribute to the formation of the unusual (coffee-like) color phenotype in TYRP1 mutant.

Indexed as

CarpsFish ProteinsGene Regulatory NetworksAnimalsChinaGene Expression ProfilingMembrane GlycoproteinsMutationOxidoreductasesPhenotypeSkin PigmentationTranscriptomeFish ProteinsMembrane GlycoproteinsOxidoreductasesCell regenerationInflammatory Autoimmune systemTyrosine metabolismTYRP1

Identifiers

PMID38956500
PMCPMC11218255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.