ReviewNature communications2024
Improving laboratory animal genetic reporting: LAG-R guidelines.
Abstract readReview
In one paragraph
Review in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Strategies for Optimizing Genetic Mouse Models to Enhance the Understanding of Parkinson's Disease.Biomedicines · 2026Review
- Improve genetic quality control to increase rigor and reproducibility of mouse research.Science (New York, N.Y.) · 2026Article
- DSS Colitis Model: Traps, Tricks, and Reporting Recommendations.Biomedicines · 2026Review
- A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- The Status and Emerging Developments in Laboratory Animal Science in Asia since 9th AFLAS Congress (2023) until 10th AFLAS Congress (2025).Animal models and experimental medicine · 2025Article
- Birth of offspring derived from cryopreserved rat sperm after shipment in a Styrofoam box at -80°C.Experimental animals · 2025Article
- Article
- Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos.Transgenic research · 2025Article
- Genome engineering with Cas9 and AAV repair templates, successes and pitfalls.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Article
- The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Review
- The mutant mouse resource and research center (MMRRC) consortium: the US-based public mouse repository system.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Review
- Animal Models of Human Pathology: Revision, Relevance and Refinements.Biomedicines · 2024Article
- The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice.G3 (Bethesda, Md.) · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors.
Lydia TeboulThe Mary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, OX11 0RD, Oxon, UK. l.teboul@har.mrc.ac.uk.ORCID http://orcid.org/0000-0002-2789-8637
James Amos-LandgrafUniversity of Missouri School of Medicine, Columbia, MO, USA.ORCID http://orcid.org/0000-0003-2535-7746
Fernando J BenavidesDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1275-4320
Marie-Christine BirlingPHENOMIN-Institut Clinique de la Souris, CELPHEDIA, CNRS, INSERM, Université de Strasbourg, Illkirch-Grafenstaden, 67404, Strasbourg, France.ORCID http://orcid.org/0000-0002-3372-8108
Steve D M BrownVisiting Scientist, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Grafenstaden, 67404, Strasbourg, France.
Elizabeth BrydaRat Resource and Research Center, University of Missouri, Columbia, MO, 65201, USA.
Rosie Bunton-StasyshynThe Mary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, OX11 0RD, Oxon, UK.ORCID http://orcid.org/0000-0002-1895-2240
Hsian-Jean ChinNational Laboratory Animal Center (NLAC), NARLabs, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-7385-8575
Martina CrispoLaboratory Animal Biotechnology Unit, Institut Pasteur de Montevideo, Mataojo 2020, CP 1400, Montevideo, Uruguay.ORCID http://orcid.org/0000-0002-9852-5563
Fabien DelerueDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7944-2108
Michael DobbiePhenomics Australia, Australian National University, 131 Garran Road, Canberra, ACT 2601, Australia.ORCID http://orcid.org/0000-0003-4226-8745
Craig L FranklinUniversity of Missouri Mutant Mouse Resource and Research Center (MU MMRRC), University of Missouri, Columbia, MO, 65201, USA.ORCID http://orcid.org/0000-0002-9198-867X
Ernst-Martin FuchtbauerDepartment of Molecular Biology, University of Aarhus, Aarhus C, 8000, Denmark.ORCID http://orcid.org/0000-0002-9320-7195
Xiang GaoNational Resource Center of Mutant Mice (NRCMM), Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China.
Christelle GolzioUniversité de Strasbourg, CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258, F-67400, Illkirch, France.ORCID http://orcid.org/0000-0002-4420-3921
Rebecca HaffnerDepartment Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0001-6503-7646
Yann HéraultPHENOMIN-Institut Clinique de la Souris, CELPHEDIA, CNRS, INSERM, Université de Strasbourg, Illkirch-Grafenstaden, 67404, Strasbourg, France.ORCID http://orcid.org/0000-0001-7049-6900
Martin Hrabe de AngelisInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-7898-2353
Kevin C Kent LloydMouse Biology Program, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-5318-4144
Terry R MagnusonDepartment of Genetics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7264, USA.ORCID http://orcid.org/0000-0002-0792-835X
Lluis MontoliuDepartment of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), 28049, Madrid, Spain.ORCID http://orcid.org/0000-0003-3941-1176
Stephen A MurrayThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0002-0594-1702
Ki-Hoan NamLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.ORCID http://orcid.org/0000-0002-0989-4456
Lauryl M J NutterGenetics and Genome Biology, The Hospital for Sick Children and The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.ORCID http://orcid.org/0000-0001-9619-146X
Eric PailhouxUniversité Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0001-8012-9143
Fernando Pardo Manuel de VillenaDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0002-5738-5795
Kevin PetersonThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0001-8353-3694
Laura ReinholdtThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0003-4054-4048
Radislav SedlacekCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-3352-392X
Je Kyung SeongLaboratory of Developmental Biology and Genomics, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, and Korea Mouse Phenotyping Center, Seoul, 08826, Republic of Korea.ORCID http://orcid.org/0000-0003-1177-6958
Toshihiko ShiroishiRIKEN BioResource Research Center (BRC), Tsukuba, Japan.ORCID http://orcid.org/0000-0003-0535-2016
Cynthia SmithMouse Genome Informatics (MGI), Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0003-3691-0324
Toru TakeoCenter for Animal Resources and Development (CARD), Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-8103-651X
Louise TinsleyThe Mary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, OX11 0RD, Oxon, UK.ORCID http://orcid.org/0000-0002-6893-2096
Jean-Luc VilotteUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0003-4623-0584
Søren WarmingGenentech, Inc., a member of the Roche group, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5721-0741
Sara WellsThe Mary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, OX11 0RD, Oxon, UK.ORCID http://orcid.org/0000-0002-0572-0600
C Bruce WhitelawThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9RG, UK.ORCID http://orcid.org/0000-0002-2918-1605
Atsushi YoshikiExperimental Animal Division, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan.ORCID http://orcid.org/0000-0002-9450-5151
Asian Mouse Mutagenesis Resource Association
CELPHEDIA infrastructure
INFRAFRONTIER consortium
International Mammalian Genome Society
International Mouse Phenotyping Consortium
International Society for Transgenic Technologies
Mutant Mouse Resource and Research Centers
Phenomics Australia
RRRC- Rat Resource and Research Center
Guillaume PavlovicPHENOMIN-Institut Clinique de la Souris, CELPHEDIA, CNRS, INSERM, Université de Strasbourg, Illkirch-Grafenstaden, 67404, Strasbourg, France. pavlovic@igbmc.fr.ORCID http://orcid.org/0000-0001-9122-4592
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MKOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7MResource Section - Core 001U42OD010924 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TERRY R MAGNUSON · 2012 to 2026
$24.5MResourceP40OD011062 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Elizabeth C Bryda · 2012 to 2026
$24.0MThe Mutant Mouse Resource and Research Center at The Jackson LaboratoryU42OD010921 · OD · JACKSON LABORATORY · PI Cathleen M Lutz · 2012 to 2026
$21.4MAgence Nationale de la Recherche (French National Research Agency) ANR-10-INBS-07Medical Research Council MC_UP_2201/1Medical Research Council MC_UP_2201/2Medical Research Council MC_UP_2201/3NCI NIH HHS P30 CA093373NHGRI NIH HHS UM1 HG006348NIH HHS P40 OD011062NIH HHS U42 OD010921NIH HHS U42 OD010924NIH HHS UM1 OD023221
Abstract
The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.
Indexed as
Animals, LaboratoryGuidelines as TopicAnimal ExperimentationAnimalsBiomedical ResearchReproducibility of ResultsResearch Design
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.