Evidence map›Paper›PMID 38956389›Full record

ArticleScientific reports2024

DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.

Vladimir Laletin, Pierre-Louis Bernard, Camille Montersino, Yuji Yamanashi, Daniel Olive, Rémy Castellano, Geoffrey Guittard, Jacques A Nunès

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. DOKing tumor progression in ccRCC.Journal of Cancer · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vladimir LaletinCentre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.
Pierre-Louis BernardCentre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.
Camille MontersinoCentre de Recherche en Cancérologie de Marseille, CRCM, TrGET Pre-Clinical Assay Platform, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.
Yuji YamanashiDivision of Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Daniel OliveCentre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.
Rémy CastellanoCentre de Recherche en Cancérologie de Marseille, CRCM, TrGET Pre-Clinical Assay Platform, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.
Geoffrey Guittard *Centre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.ORCID 0000-0002-6061-8553
Jacques A Nunès *Centre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France. jacques.nunes@inserm.fr.ORCID 0000-0003-4865-0400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting intracellular inhibiting proteins has been revealed to be a promising strategy to improve CD8

Indexed as

Adaptor Proteins, Signal TransducingCD8-Positive T-LymphocytesDNA-Binding ProteinsImmunologic MemoryMice, KnockoutPhosphoproteinsReceptors, Antigen, T-CellRNA-Binding ProteinsSignal TransductionAnimalsCell Line, TumorMiceMice, TransgenicAdaptor Proteins, Signal TransducingDNA-Binding ProteinsDok1 protein, mouseDok2 protein, mousePhosphoproteinsReceptors, Antigen, T-CellRNA-Binding Proteins

Identifiers

PMID38956389
PMCPMC11220026

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.