Evidence map›Paper›PMID 38956019›Full record

ArticleNature communications2024

Ligand-enabled ruthenium-catalyzed meta-C-H alkylation of (hetero)aromatic carboxylic acids.

Xianglin Luo, Peichao Hou, Jiayi Shen, Yifeng Kuang, Fengchao Sun, Huanfeng Jiang, Lukas J Gooßen, Liangbin Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xianglin LuoKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China.
Peichao HouKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China.
Jiayi ShenKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China.
Yifeng KuangKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China.
Fengchao SunKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China.
Huanfeng JiangKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China.ORCID http://orcid.org/0000-0002-4355-0294
Lukas J GooßenRuhr-Universität Bochum Lehrstuhl für Organische Chemie, Universitätsstraße 150, 44801, Bochum, Germany. lukas.goossen@ruhr-uni-bochum.de.ORCID http://orcid.org/0000-0002-2547-3037
Liangbin HuangKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 510641, Guangzhou, China. huanglb@scut.edu.cn.ORCID http://orcid.org/0000-0001-9450-9454

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) EXC 2033-390677874-RESOLVNational Natural Science Foundation of China (National Science Foundation of China) 21971074Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2021A1515220024Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2022A1515010660
6 · The paper itself

Abstract

Carboxylates are ideal directing groups because they are widely available, readily cleavable and excellent linchpins for diverse follow-up reactions. However, their use in meta-selective C-H functionalizations remains a substantial unmet catalytic challenge. Herein, we report the ruthenium-catalyzed meta-C-H alkylation of aromatic carboxylic acids with various functionalized alkyl halides. A bidentate N-ligand increases the electron density at the metal center of ortho-benzoate ruthenacycles to the extent that single-electron reductions of alkyl halides can take place. The subsequent addition of alkyl radicals is exclusively directed to the position para to the C

Identifiers

PMID38956019
PMCPMC11219896

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.