Evidence map›Paper›PMID 38955983›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

Social determinants of health and sepsis: a case-control study.

Fatima Sheikh, William Douglas, Yi David Diao, Rebecca H Correia, Rachel Gregoris, Christina Machon, Neil Johnston, Alison E Fox-Robichaud, Sepsis Canada

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PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fatima SheikhDepartment of Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. sheikf9@mcmaster.ca.ORCID 0000-0002-1327-2203
William DouglasDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Yi David DiaoDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Rebecca H CorreiaDepartment of Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Rachel GregorisDepartment of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Christina MachonDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Neil JohnstonDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Alison E Fox-RobichaudHamilton Health Sciences, Hamilton, ON, Canada.
Sepsis Canada

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to identify whether social determinants of health (SDoH) are associated with the development of sepsis and assess the differences between individuals living within systematically disadvantaged neighbourhoods compared with those living outside these neighbourhoods.

methodsWe conducted a single-centre case-control study including 300 randomly selected adult patients (100 patients with sepsis and 200 patients without sepsis) admitted to the emergency department of a large academic tertiary care hospital in Hamilton, ON, Canada. We collected data on demographics and a limited set of SDoH variables, including neighbourhood household income, smoking history, social support, and history of alcohol disorder. We analyzed study data using multivariate logistic regression models.

resultsThe study included 100 patients with sepsis with a median [interquartile range (IQR)] age of 75 [58-84] yr and 200 patients without sepsis with a median [IQR] age of 72 [60-83] yr. Factors significantly associated with sepsis included arrival by ambulance, absence of a family physician, higher Hamilton Early Warning Score, and a recorded history of dyslipidemia. Important SDoH variables, such as individual or household income and race, were not available in the medical chart. In patients with SDoH available in their medical records, no SDoH was significantly associated with sepsis. Nevertheless, compared with their proportion of the Hamilton population, the rate of sepsis cases and sepsis deaths was approximately two times higher among patients living in systematically disadvantaged neighbourhoods.

conclusionsThis study revealed the lack of available SDoH data in electronic health records. Despite no association between the SDoH variables available and sepsis, we found a higher rate of sepsis cases and sepsis deaths among individuals living in systematically disadvantaged neighbourhoods. Including SDoH in electronic health records is crucial to study their effect on the risk of sepsis and to provide equitable care.

Indexed as

SepsisSocial Determinants of HealthAgedAged, 80 and overCase-Control StudiesEmergency Service, HospitalFemaleHumansLogistic ModelsMaleMiddle AgedResidence CharacteristicsRisk FactorsSocial Supportearly warning scoresemergency departmenthealth equitysocial determinants of health

Identifiers

PMID38955983
PMCPMC11493815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.