Evidence map›Paper›PMID 38955937›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Identification of Differentially Expressed mRNAs and lncRNAs Contributes to Elucidation of Underlying Pathogenesis and Therapeutic Strategy of Recurrent Implantation Failure.

Lin Liu, Yidan Liu, Yu Tian, Ying Cao, Ting Wang, Shengyan Mi, Run Yang, Simin Liu, Xiaoling Ma, Jing Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lin Liu *The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China. ldyy_liul@lzu.edu.cn.ORCID 0000-0002-4778-4442
Yidan Liu *The Basic Medical Sciences College of Lanzhou University, Lanzhou, Gansu, China.
Yu Tian *The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Ying Cao *Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Ting Wang *The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Shengyan MiThe First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Run YangSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Simin LiuSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Xiaoling MaThe First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China. maxl2005@163.com.
Jing WangSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu, China. jwang_2017@hotmail.com.

Funding

First Clinical Medical School, Lanzhou University 20220060073First Clinical Medical School, Lanzhou University 20220060074First Clinical Medical School, Lanzhou University ldyyyn2022-60Innovation and Entrepreneurship Talent Project of Lanzhou 2022-RC-47Lanzhou Science and Technology Bureau 2023-ZD-93Lanzhou University lzuyxcx-2022-191National Natural Science Foundation of China 82360307Science and Technology Program of Gansu Province 20JR10TA715Science and Technology Program of Gansu Province 21JR7RA391
6 · The paper itself

Abstract

Recurrent implantation failure (RIF) is a complex and poorly understood clinical disorder characterized by failure to conceive after repeated embryo transfers. Endometrial receptivity (ER) is a prerequisite for implantation, and ER disorders are associated with RIF. However, little is known regarding the molecular mechanisms underlying ER in RIF. In the present study, RNA sequencing data from the mid-secretory endometrium of patients with and without RIF were analyzed to explore the potential long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) involved in RIF. The analysis revealed 213 and 1485 differentially expressed mRNAs and lncRNAs, respectively (fold change ≥ 2 and p < 0.05). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated that these genes were mostly involved in processes related to immunity or inflammation. 5 key genes (TTR, ALB, TF, AFP, and CFTR) and a key module including 14 hub genes (AFP, ALB, APOA1, APOA2, APOB, APOH, FABP1, FGA, FGG, GC, ITIH2, SERPIND1, TF and TTR) were identified in the protein-protein interaction (PPI) network. The 5 key genes were used to further explore the lncRNA-miRNA-mRNA regulatory network. Finally, the drug ML-193 based on the 14 hub genes was identifed through the CMap. After ML-193 treatment, endometrial cell proliferation was increased, the hub genes were mostly down-regulated, and the ER marker HOXA10 was up-regulated. These results offer insights into the regulatory mechanisms of lncRNAs and mRNAs and suggest ML-193 as a therapeutic agent for RIF by enhancing ER.

Indexed as

Embryo ImplantationEndometriumInfertility, FemaleRNA, Long NoncodingRNA, MessengerAdultEmbryo TransferFemaleGene Regulatory NetworksHumansRNA, Long NoncodingRNA, MessengerCompeting endogenous RNAEndometrial receptivityLong non-coding RNAMessenger RNAML-193Recurrent implantation failure

Identifiers

PMID38955937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.