Evidence map›Paper›PMID 38955910›Full record

ArticleMolecular and cellular biochemistry2025

RIP3 orchestrates oxidative stress and pyroptosis in doxorubicin-induced cardiotoxicity through regulation of AKT/Nrf2 signaling cascade.

Zhenyi Wang, Yitong Yang, Nisha Wang, Linhe Lu, Chennian Xu, Jun Ren, Lifang Yang

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In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhenyi Wang *Department of Anesthesiology, Children's Hospital Affiliated to Xi'an Jiao Tong University, Xi'an, 710003, Shaanxi, China.
Yitong Yang *Department of Children's Respiratory Asthma, Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xian Yang, 712046, Shaanxi, China.
Nisha Wang *Department of Anesthesiology, Children's Hospital Affiliated to Xi'an Jiao Tong University, Xi'an, 710003, Shaanxi, China.
Linhe LuDepartment of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
Chennian XuKey Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Jun RenDepartment of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhong Shan Hospital Fudan University, Shanghai, China.
Lifang YangDepartment of Anesthesiology, Children's Hospital Affiliated to Xi'an Jiao Tong University, Xi'an, 710003, Shaanxi, China. yanglf@fmmu.edu.cn.

Funding

National Natural Science Foundation of China 81774415National Natural Science Foundation of China 92249301Outstanding Youth Foundation of Shaanxi Province 2021JC-49Xi'an Talent Program XAYC210024
6 · The paper itself

Abstract

This study was designed to explore the role of RIP3 in DOX-induced cardiotoxicity and its underlying molecular mechanisms. Our results demonstrate that RIP3 exacerbates DOX-induced cardiotoxicity through promoting oxidative stress and pyroptosis by regulating the AKT/Nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathway. Inhibition of RIP3 using GSK-872 attenuated DOX-induced cardiac remodeling and contractile dysfunction. Moreover, using GSK-872 in vivo, the results revealed that inhibition of RIP3 alleviated DOX-induced cardiotoxicity by the resulting inhibition of oxidative stress and pyroptosis. In addition, inhibition of RIP3 increased the protein levels of AKT and Nrf2 in DOX-treated mouse hearts. Furthermore, the AKT inhibitor LY294002 lessened RIP3 reduction-offered protection against DOX-induced H9c2 cell injury by moderating oxidative stress and pyroptosis. Taken together, these data demonstrate that RIP3 activation orchestrates DOX-induced cardiotoxicity through elevated oxidative stress and pyroptosis in an AKT/Nrf2-dependent manner. Those findings highlight the clinical relevance and therapeutic potential of targeting RIP3 for the treatment of DOX-induced cardiotoxicity.

Indexed as

CardiotoxicityDoxorubicinNF-E2-Related Factor 2Oxidative StressProto-Oncogene Proteins c-aktPyroptosisReceptor-Interacting Protein Serine-Threonine KinasesSignal TransductionAnimalsCell LineMaleMiceMyocytes, CardiacRatsDoxorubicinNfe2l2 protein, mouseNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktReceptor-Interacting Protein Serine-Threonine KinasesRipk3 protein, mouseCardiotoxicityDoxorubicinOxidative stressPyroptosisRIP3

Identifiers

PMID38955910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.