ArticleJournal of assisted reproduction and genetics2024
The effects of age, mature oocyte number, and cycle number on cumulative live birth rates after planned oocyte cryopreservation.
Article in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Planned oocyte cryopreservation (POC): a longitudinal study of patient experience.Journal of assisted reproduction and genetics · 2026Article
- Planned Oocyte Cryopreservation Following the 2021 French Bioethics Law: Women's Characteristics and Early Clinical Outcomes From a Single-Center Observational Study.Journal of pregnancy · 2026Observational
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Authors and funding
6 authors.
Funding
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Abstract
purposeTo examine the effects of age, mature oocyte number, and cycle number on cumulative live birth rates after planned oocyte cryopreservation (OC), with the goal of developing a patient counselling tool.
methodsWe performed a retrospective cohort study of all patients with ≥ 1 autologous oocyte thaw at our university-affiliated fertility center before 12/31/2023. Patients were included if they (1) had a live birth or ongoing pregnancy > 12 weeks from OC, or (2) used all oocytes and euploid/untested embryos from OC. Primary outcome was cumulative live birth / ongoing pregnancy rate (CLBR).
results527 patients with 1 OC cycle, 149 patients with 2 OC cycles, and 55 patients with ≥ 3 OC cycles were included. Overall CLBR was 43%. CLBR was > 70% among patients who thawed ≥ 20 mature oocytes that were cryopreserved at age < 38 years. Multiple logistic regression showed that age at first OC and total number of mature oocytes thawed independently predicted CLBR, but number of OC cycles did not.
conclusionPatients must be counselled that younger age at OC and more mature oocytes improve CLBR. However, additional OC cycles do not independently improve CLBR. Our results can help patients decide whether to pursue additional OC cycles to obtain more oocytes.
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