Evidence map›Paper›PMID 38955846›Full record

ArticleEuropean journal of pediatrics2024

Mortality and neurodevelopmental outcomes at 2 years' corrected age of very preterm infants with necrotising enterocolitis or spontaneous intestinal perforation: The EPIPAGE-2 cohort study.

Victoria Butler, Ludovic Treluyer, Juliana Patkaï, Aline Biset, Pierre-Henri Jarreau, Pierre-Yves Ancel, Jean-Christophe Rozé, Laetitia Marchand-Martin, Mélanie Durox, Alexandre Lapillonne and 11 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07207915 (Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07207915 completednot on this map

Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis

TypeobservationalSponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2023 to 2025Enrolled400ConditionsNecrotizing EnterocolitisArmsObservational retrospective cohort study
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Victoria ButlerNeonatal Intensive Care Unit, Assistance Publique - Hôpitaux de Paris, Paris Cité University, Cochin Hospital, 53 Avenue de L'Observatoire, Paris, 75014, France. victoria.butler@aphp.fr.
Ludovic TreluyerNeonatal Intensive Care Unit, Assistance Publique - Hôpitaux de Paris, Paris Cité University, Cochin Hospital, 53 Avenue de L'Observatoire, Paris, 75014, France.
Juliana PatkaïNeonatal Intensive Care Unit, Assistance Publique - Hôpitaux de Paris, Paris Cité University, Cochin Hospital, 53 Avenue de L'Observatoire, Paris, 75014, France.
Aline BisetDepartment of Neonatal Paediatrics, Trousseau Hospital, Assistance Publique - Hôpitaux de Paris, Sorbonne University, Paris, France.
Pierre-Henri JarreauNeonatal Intensive Care Unit, Assistance Publique - Hôpitaux de Paris, Paris Cité University, Cochin Hospital, 53 Avenue de L'Observatoire, Paris, 75014, France.
Pierre-Yves AncelParis Cité University, Centre of Research in Epidemiology and StatisticS (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé), INSERM, INRAE, Paris, 75006, France.
Jean-Christophe RozéNutrition EPIPAGE-2 Study Group, Paris, France.
Laetitia Marchand-MartinParis Cité University, Centre of Research in Epidemiology and StatisticS (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé), INSERM, INRAE, Paris, 75006, France.
Mélanie DuroxParis Cité University, Centre of Research in Epidemiology and StatisticS (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé), INSERM, INRAE, Paris, 75006, France.
Alexandre LapillonneNutrition EPIPAGE-2 Study Group, Paris, France.
Jean-Charles PicaudNutrition EPIPAGE-2 Study Group, Paris, France.
Delphine MitanchezNutrition EPIPAGE-2 Study Group, Paris, France.
Charlotte TscherningNutrition EPIPAGE-2 Study Group, Paris, France.
Valérie BiranNutrition EPIPAGE-2 Study Group, Paris, France.
Gilles CambonieNutrition EPIPAGE-2 Study Group, Paris, France.
Emmanuel LopezNutrition EPIPAGE-2 Study Group, Paris, France.
Jean-Michel HascoetNutrition EPIPAGE-2 Study Group, Paris, France.
Luc DesfrereNutrition EPIPAGE-2 Study Group, Paris, France.
Clément ChollatDepartment of Neonatal Paediatrics, Trousseau Hospital, Assistance Publique - Hôpitaux de Paris, Sorbonne University, Paris, France.
Elodie Zana-TaïebNeonatal Intensive Care Unit, Assistance Publique - Hôpitaux de Paris, Paris Cité University, Cochin Hospital, 53 Avenue de L'Observatoire, Paris, 75014, France.
Héloïse TorchinNeonatal Intensive Care Unit, Assistance Publique - Hôpitaux de Paris, Paris Cité University, Cochin Hospital, 53 Avenue de L'Observatoire, Paris, 75014, France.

Funding

Apicil Foundation R20065KKCentre National de la Recherche Scientifique ANR-11-EQPX-0038 and ANR-19-COHO001Epinutri DGOS13-040Fondation de France 11779Fondation pour la Recherche Médicale SPF20160936356Ministère de l'Enseignement Supérieur, De La Recherche et de L'Innovation G13129KK
6 · The paper itself

Abstract

purposeThe primary objective was to evaluate the impact of necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP) on mortality and neurodevelopmental outcomes at 2 years' corrected age (CA) in infants born before 32 weeks' gestation (WG).

methodsWe studied neurodevelopment at 2 years' CA of infants with NEC or SIP who were born before 32 WG from the EPIPAGE-2 cohort study. The primary outcome was death or the presence of moderate-to-severe motor or sensory disability defined by moderate-to-severe cerebral palsy or hearing or visual disability. The secondary outcome was developmental delay defined by a score < 2 SDs below the mean for any of the five domains of the Ages and Stages Questionnaire.

resultsAt 2 years' CA, 46% of infants with SIP, 34% of infants with NEC, and 14% of control infants died or had a moderate-to-severe sensorimotor disability (p < 0.01). This difference was mainly due to an increase in in-hospital mortality in the infants with SIP or NEC. Developmental delay at 2 years' CA was more frequent for infants with SIP than controls (70.8% vs 44.0%, p = 0.02) but was similar for infants with NEC and controls (49.3% vs 44.0%, p = 0.5). On multivariate analysis, the likelihood of developmental delay was associated with SIP (adjusted odds ratio = 3.0, 95% CI 1.0-9.1) but not NEC as compared with controls.

conclusionNEC and SIP significantly increased the risk of death or sensorimotor disability at 2 years' CA. SIP was also associated with risk of developmental delay at 2 years' CA.

Indexed as

Developmental DisabilitiesEnterocolitis, NecrotizingInfant, Premature, DiseasesIntestinal PerforationCase-Control StudiesChild, PreschoolCohort StudiesFemaleFollow-Up StudiesHospital MortalityHumansInfantInfant, Extremely PrematureInfant, NewbornInfant, PrematureMaleDigestive surgeryMortalityNecrotizing enterocolitisNeurodevelopmentPrematuritySpontaneous intestinal perforation

Identifiers

PMID38955846

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Registered trials

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