ArticleRMD open2024
Twenty-year trajectories of morbidity in individuals with and without osteoarthritis.
Article in RMD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Irisin in Cartilage Homeostasis: Molecular Mechanisms and Therapeutic Implications for Osteoarthritis.Journal of functional morphology and kinesiology · 2026Review
- [Study on the effect of superficial layer damage on cartilage retention performance].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Multimorbidity as a predictor of mortality in companion dogs.GeroScience · 2026Article
- Trends in prevalence and disability burden of main rheumatic and musculoskeletal diseases in France 2008-2022.RMD open · 2026Article
- Article
- Age-specific comorbidity risks in osteoarthritis: implications for healthy aging across diverse populations.Archives of public health = Archives belges de sante publique · 2025Article
- Inhibition of mTORC1 by rapamycin results in feedback activation of AktbioRxiv : the preprint server for biology · 2025Article
- Trajectories of physical, mental health and health satisfaction before and after arthritis diagnosis: a UK population-based study.BMC musculoskeletal disorders · 2025Article
- Osteoarthritis.Nature reviews. Disease primers · 2025Review
- Supervised or Home-Based? Exploring the Best Exercise Approach for Knee Osteoarthritis Management: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- The severity of depressive symptoms as a mediator in the sleep-osteoarthritis risk pathway: insights from the ELSA cohort.Frontiers in nutrition · 2025Article
- Longitudinal study on health-related quality of life and multimorbidity: from trajectories to outcomes in China.Frontiers in public health · 2025Article
- Twenty-year trajectories of morbidity in individuals with and without osteoarthritis.RMD open · 2024Article
- Global, regional, and national burdens of osteoarthritis from 1990 to 2021: findings from the 2021 global burden of disease study.Frontiers in medicine · 2024Article
- Validation of Jianpi Qingre Tongluo Recipe in Reducing Inflammation and Dyslipidemia in Osteoarthritis via Lnc RNA HOTAIR/APN/PI3K/AKT.International journal of general medicine · 2024Article
- Illness Intrusiveness, Perceived Control, and Quality of Life in Older Adults with Arthritis and Multimorbidity.Clinical gerontologistArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify multimorbidity trajectories over 20 years among incident osteoarthritis (OA) individuals and OA-free matched references.
methodsCohort study using prospectively collected healthcare data from the Skåne region, Sweden (~1.4 million residents). We extracted diagnoses for OA and 67 common chronic conditions. We included individuals aged 40+ years on 31 December 2007, with incident OA between 2008 and 2009. We selected references without OA, matched on birth year, sex, and year of death or moving outside the region. We employed group-based trajectory modelling to capture morbidity count trajectories from 1998 to 2019. Individuals without any comorbidity were included as a reference group but were not included in the model.
resultsWe identified 9846 OA cases (mean age: 65.9 (SD 11.7), female: 58%) and 9846 matched references. Among both cases and references, 1296 individuals did not develop chronic conditions (no-chronic-condition class). We identified four classes. At the study outset, all classes exhibited a low average number of chronic conditions (≤1). Class 1 had the slowest progression towards multimorbidity, which increased progressively in each class. Class 1 had the lowest count of chronic conditions at the end of the follow-up (mean: 2.9 (SD 1.7)), while class 4 had the highest (9.6 (2.6)). The presence of OA was associated with a 1.29 (1.12, 1.48) adjusted relative risk of belonging to class 1 up to 2.45 (2.12, 2.83) for class 4.
conclusionsOur findings suggest that individuals with OA face an almost threefold higher risk of developing severe multimorbidity.
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