Evidence map›Paper›PMID 38954723›Full record

ReviewPLOS global public health2024

Optimizing the cascade of prevention to protect people from tuberculosis: A potential game changer for reducing global tuberculosis incidence.

Alberto Matteelli, Gavin Churchyard, Daniela Cirillo, Saskia den Boon, Dennis Falzon, Yohhei Hamada, Rein M G J Houben, Avinash Kanchar, Afrânio Kritski, Blessina Kumar and 3 more

Abstract readReview
In one paragraph

Review in PLOS global public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alberto MatteelliInstitute of Infectious and Tropical Diseases, WHO Collaborating Centre for Tuberculosis Prevention, University of Brescia, Brescia, Italy.
Gavin ChurchyardThe Aurum Institute, Parktown, South Africa, School of Public Health, University of Witwatersrand, Johannesburg, South Africa.
Daniela CirilloIRCCS San Raffaele Scientific Institute, Milan, Italy.
Saskia den BoonGlobal Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
Dennis FalzonGlobal Tuberculosis Programme, World Health Organization, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-8798-7909
Yohhei HamadaResearch Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9845-4267
Rein M G J HoubenTB Modelling Group, TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Avinash KancharGlobal Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
Afrânio KritskiRede Brasileira de Pesquisa em Tuberculose, REDE TB, Rio de Janeiro, Brasil.
Blessina KumarThe Global Coalition of TB Advocates, India.ORCID https://orcid.org/0009-0008-0143-8975
Cecily MillerGlobal Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
Dick MenziesMcGill International TB Centre, McGill University, Montreal, Quebec, Canada.
Tiziana MasiniIndependent consultant, Lucca, Italy.ORCID https://orcid.org/0000-0003-0400-1919

Funding

Aurum Clinical Trials UnitUM1AI154463 · NIAID · AURUM INSTITUTE NPC · PI Gavin John Churchyard · 2021 to 2026
$8.1M
NIAID NIH HHS UM1 AI154463World Health Organization 001
6 · The paper itself

Abstract

The provision of tuberculosis preventive treatment is one of the critical interventions to reduce tuberculosis incidence and ultimately eliminate the disease, yet we still miss appropriate tools for an impactful intervention and treatment coverage remains low. We used recent data, epidemiological estimates, and research findings to analyze the challenges of each step of the cascade of tuberculosis prevention that currently delay the strategy implementation. We addressed research gaps and implementation bottlenecks that withhold key actions in tuberculosis case finding, testing for tuberculosis infection, provision of preventive treatment with safer, shorter regimens and supporting people to complete their treatment. Empowering communities to generate demand for preventive therapy and other prevention services in a holistic manner and providing adequate financial support to sustain implementation are essential requirements. The adoption of an effective, universal monitoring and evaluation system is a prerequisite to provide general and granular insight, and to steer progress of the tuberculosis infection strategy at global and local level.

Identifiers

PMID38954723
PMCPMC11218967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.