Evidence map›Paper›PMID 38954698›Full record

ArticlePloS one2024

Iron gallic acid biomimetic nanoparticles for targeted magnetic resonance imaging.

Yan Chen, Zhaohui Zhang, Zhijian Chen, Shiqing Jiang, Aikebaier Reheman, Yifan Ouyang, Bo Yu, Qiuyan Chen, Dingtai Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan ChenFujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Ningde, Fujian, China.ORCID 0000-0001-8998-8489
Zhaohui ZhangFujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Ningde, Fujian, China.
Zhijian ChenFunctional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China.
Shiqing JiangPharmacy Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China.
Aikebaier RehemanFujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Ningde, Fujian, China.
Yifan OuyangFujian Key Laboratory of Toxicant and Drug Toxicology, Ningde Normal University, Ningde, Fujian, China.
Bo YuFunctional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China.
Qiuyan ChenFunctional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China.
Dingtai WeiFunctional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing T1-weighted magnetic resonance imaging (MRI) contrast agents with enhanced biocompatibility and targeting capabilities is crucial owing to concerns over current agents' potential toxicity and suboptimal performance. Drawing inspiration from "biomimetic camouflage," we isolated cell membranes (CMs) from human glioblastoma (T98G) cell lines via the extrusion method to facilitate homotypic glioma targeting. At an 8:1 mass ratio of ferric chloride hexahydrate to gallic acid (GA), the resulting iron (Fe)-GA nanoparticles (NPs) proved effective as a T1-weighted MRI contrast agent. T98G CM-coated Fe-GA NPs demonstrated improved homotypic glioma targeting, validated through Prussian blue staining and in vitro MRI. This biomimetic camouflage strategy holds promise for the development of targeted theranostic agents in a safe and effective manner.

Indexed as

Contrast MediaGallic AcidMagnetic Resonance ImagingBiomimetic MaterialsCell Line, TumorCell MembraneFerric CompoundsGlioblastomaHumansIronNanoparticlesContrast MediaFerric CompoundsGallic AcidIron

Identifiers

PMID38954698
PMCPMC11218937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.