Evidence map›Paper›PMID 38954295›Full record

ArticleBulletin of experimental biology and medicine2024

The Influence of Maternal Hypoxia and Buspirone during Pregnancy on Cognitive Abilities and a Stress Response in Adult Male Offspring.

V A Mikhailenko, I P Butkevich, E A Vershinina

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

V A MikhailenkoLaboratory of Ontogenesis of Nervous System, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. viktormikhailenko@yandex.ru.
I P ButkevichLaboratory of Ontogenesis of Nervous System, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
E A VershininaLaboratory of Information Technologies and Mathematical Modeling, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial learning, memory, and reactivity of the hypothalamic-pituitary-adrenocortical system (HPA axis) were studied in adult male rats, whose mothers during pregnancy were subjected to acute moderate normobaric hypoxia, or repeated injections of buspirone, an agonist of type 1A serotonergic receptors (5HT1A), or their combination. Prenatal treatment with buspirone in rats with prenatal hypoxia impaired learning ability during the first day of 5-day training. A decrease in the effectiveness of long-term memory in comparison with short-term memory was revealed in two groups of rats: prenatal treatment with buspirone in combination with hypoxia and injection of physiological saline without hypoxia. The effectiveness of long-term memory and the level of corticosterone in response to stress did not differ between the groups, which can indicate adaptation of the 5HT1A receptor and the HPA axis to the prenatal buspirone and normobaric hypoxia during ontogeny.

Indexed as

BuspironeHypothalamo-Hypophyseal SystemHypoxiaPrenatal Exposure Delayed EffectsAnimalsCognitionCorticosteroneFemaleMaleMaze LearningMemory, Long-TermPituitary-Adrenal SystemPregnancyRatsRats, WistarReceptor, Serotonin, 5-HT1ABuspironeCorticosteroneReceptor, Serotonin, 5-HT1Abuspironecorticosteronememoryprenatal hypoxiaspatial learning

Identifiers

PMID38954295

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.