Evidence map›Paper›PMID 38954290›Full record

ArticleInsights into imaging2024

Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI.

Shengfang Xu, Zihan Ma, Jinlong Zhang, Shaoyu Wang, Xin Ge, Songhong Yue, Xinyi Li, Jifang Qian, Dalin Zhu, Guangyao Liu and 1 more

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Article in Insights into imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Shengfang XuSecond Clinical School, Lanzhou University, Lanzhou, Gansu, China.
Zihan MaMedical Imaging Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu, China.
Jinlong ZhangPulmonary and Critical Care Medicine, The 940th Hospital of the Joint Logistic Support Force of the People's Liberation Army, Lanzhou, Gansu, China.
Shaoyu WangMR Research Collaboration, Siemens Healthineers, Shanghai, China.
Xin GeSecond Clinical School, Lanzhou University, Lanzhou, Gansu, China.
Songhong YueSecond Clinical School, Lanzhou University, Lanzhou, Gansu, China.
Xinyi LiMedical Imaging Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu, China.
Jifang QianMedical Imaging Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu, China.
Dalin ZhuMedical Imaging Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu, China.
Guangyao LiuSecond Clinical School, Lanzhou University, Lanzhou, Gansu, China.
Jing ZhangSecond Clinical School, Lanzhou University, Lanzhou, Gansu, China. ery_zhangjing@lzu.edu.cn.ORCID http://orcid.org/0000-0002-1678-5688

Funding

This study has received funding by the science and Technology Project of Gansu Province (NO.23JRRA1744 and NO.21JR7RA438), Lanzhou Science and Technology Bureau of Gansu Province (No. 2022-5-78), and Health Industry Scientific Research Program of Gansu Pro (NO.23JRRA1744 and NO.21JR7RA438);(No. GSWSKY2021-059)(No. 2022-5-78);
6 · The paper itself

Abstract

objectivesThis study investigated the quantitative assessment and application of Synthetic MRI (SyMRI) for preoperative brain development in children with congenital heart disease (CHD).

methodsForty-three CHD patients aged 2-24 months were prospectively included in the observation group, and 43 healthy infants were included in the control group. The SyMRI scans were processed by postprocessing software to obtain T1, T2, and PD maps. The values of T1, T2, and PD in different brain regions were compared with the scores of the five ability areas of the Gesell Development Scale by Pearson correlation analysis.

resultsIn the observation group, the T1 values of the posterior limb of the internal capsule (PLIC), Optic radiation (PTR), cerebral peduncle, centrum semiovale, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. In the observation group, the T2 values of the PLIC, PTR, frontal white matter, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. Pearson correlation analysis revealed that the observation group had significantly lower Development Scale scores. In the observation group, the T2 value of the splenium of the corpus callosum was significantly positively correlated with the personal social behavior score. The AUCs for diagnosing preoperative brain developmental abnormalities in children with CHD using T1 values of the temporal white matter and dentate nucleus were both greater than 0.60.

conclusionsQuantitative assessment using SyMRI can aid in the early detection of preoperative brain development abnormalities in children with CHD. CRITICAL RELEVANCE STATEMENT: T1 and T2 relaxation values from SyMRI can be considered as a quantitative imaging marker to detect abnormalities, allowing for early clinical evaluation and timely intervention, thereby reducing neurodevelopmental disorders in these children. KEY POINTS: T1 and T2 relaxation values by SyMRI are related to myelin development. Evaluated development quotient markers were lower in the observation compared to the control group. SyMRI can act as a reference indicator for brain development in CHD children.

Indexed as

Brain developmentCongenital heart diseaseInfantsSynthetic magnetic resonance imaging

Identifiers

PMID38954290
PMCPMC11219600

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.