Evidence map›Paper›PMID 38954189›Full record

ArticleJournal of gastrointestinal cancer2024

Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer.

Anne-Sophie Dulac, Pietro Genova, Olivier Benoit, Cindy Neuzillet, Mostapha El Hajjam, Jean-François Emile, Frédérique Peschaud, Renato Micelli Lupinacci

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne-Sophie DulacAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Oncologic Surgery, Ambroise-Paré Hospital, 9 Avenue Charles de Gaulle - 92104, Boulogne-Billancourt, France.
Pietro GenovaAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Oncologic Surgery, Ambroise-Paré Hospital, 9 Avenue Charles de Gaulle - 92104, Boulogne-Billancourt, France.
Olivier BenoitAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Oncologic Surgery, Ambroise-Paré Hospital, 9 Avenue Charles de Gaulle - 92104, Boulogne-Billancourt, France.
Cindy NeuzilletInstitut Curie, Versailles Saint-Quentin University - Paris Saclay University, Saint-Cloud, France.
Mostapha El HajjamAssistance Publique-Hôpitaux de Paris (AP-HP), Ambroise-Paré Hospital, Department of Radiology, Boulogne-Billancourt, France.
Jean-François EmileVersailles St-Quentin-en-Yvelines/Paris Saclay University, UFR Des Sciences de la santé Simone Veil, 78180, Montigny-Le-Bretonneux, France.
Frédérique PeschaudAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Oncologic Surgery, Ambroise-Paré Hospital, 9 Avenue Charles de Gaulle - 92104, Boulogne-Billancourt, France.
Renato Micelli LupinacciAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Oncologic Surgery, Ambroise-Paré Hospital, 9 Avenue Charles de Gaulle - 92104, Boulogne-Billancourt, France. renato.lupinacci@aphp.fr.ORCID http://orcid.org/0000-0003-2527-7949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTreatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant radiotherapy. We report the outcomes of a curative intent strategy in a recent monocentric series of patients.

methodsWe did a retrospective review of all curative intent surgical treatment of RPN from CC performed consecutively in a French university hospital from June 2015 to April 2021. Demographics, clinicopathological, and molecular characteristics were evaluated. We describe recurrence-free and overall survival and factors related to recurrence.

resultsRecords from 18 patients were reviewed. The median age was 69 years. Most of the patients were male (55%), ASA 1-2 (94%), had a left-sided primary colon cancer (73%), and had metachronous RPN (62%). Thirteen patients (72%) experienced recurrence. Recurrence was often limited to RPN (27%) or liver (22%). Four patients underwent a second surgery for RPN recurrence. Median disease-free and overall survival were 22 months and 50 months after RPN surgery. We did not find any factor associated with recurrence. Short-term recurrence (< 6 months) was associated with shorter overall survival (0.031).

conclusionThe current results suggest that RPN resection is feasible and associated with long survival in selected patients. Further studies evaluating the benefit of curative strategies including radical surgery for patients with potentially resectable RPN are warranted.

Indexed as

Colonic NeoplasmsLymphatic MetastasisRetroperitoneal NeoplasmsAgedAged, 80 and overDisease-Free SurvivalFemaleHumansLymph Node ExcisionLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesColorectal cancerMetastasesPrognosisRecurrenceRetroperitoneal lymph nodes

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.