Evidence map›Paper›PMID 38954150›Full record

ArticleJournal of clinical immunology2024

Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis.

Elise M N Ferré, Diana X Nichols-Vinueza, Lindsey B Rosen, Peter D Burbelo, Kevin P Fennelly, Joseph Pechacek, Daniel M Goldstein, Anahita Agharahimi, Annapurna Saksena, David E Kleiner and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Elise M N Ferré *Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Diana X Nichols-Vinueza *Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Lindsey B RosenLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Peter D BurbeloNational Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, MD, USA.
Kevin P FennellyPulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
Joseph PechacekLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Daniel M GoldsteinLaboratory of Chronic Airway Infection, NHLBI, NIH, Bethesda, MD, USA.
Anahita AgharahimiLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Annapurna SaksenaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.
David E KleinerLaboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.
Yesim Yilmaz DemirdagDepartment of Medicine, Division of Basic and Clinical Immunology, University of California of Irvine, Irvine, CA, USA.
Arun RajanThoracic and Gastrointestinal Malignancies Branch, NCI, NIH, Bethesda, MD, USA.
David S SchrumpThoracic Surgery Branch, NCI, NIH, Bethesda, MD, USA.
Steven M HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Michail S LionakisLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. lionakism@mail.nih.gov.

Funding

Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
Thoracic Surgery Consultative ServicesZIDBC011911 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHRUMP, DAVID · 2019 to 2025
$2.6M
6 · The paper itself

Abstract

backgroundThymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency. Pneumonitis has recently been described as an autoimmune manifestation associated with thymoma presenting with similar clinical, radiographic, histological, and autoantibody features as seen in patients with inherited AIRE deficiency who suffer from Autoimmune PolyEndocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) syndrome.

objectivesTo treat two patients with biopsy-proven thymoma-associated pneumonitis with lymphocyte-directed immunomodulation.

methodsTwo patients with thymoma were enrolled on IRB-approved protocols at the NIH Clinical Center. We performed history and physical examination; laboratory, radiographic, histologic and pulmonary function evaluations; and measurement of the lung-directed autoantibodies KCNRG and BPIFB1 prior to and at 1- and 6-months following initiation of lymphocyte-directed immunomodulation with azathioprine with or without rituximab.

resultsCombination T- and B-lymphocyte-directed immunomodulation resulted in improvement of clinical, functional, and radiographic parameters at 6-month follow-up evaluations in both patients with sustained remission up to 12-36 months following treatment initiation.

conclusionLymphocyte-directed immunomodulation remitted autoimmune pneumonitis in two patients with thymoma.

Indexed as

ImmunomodulationThymomaAdultAutoantibodiesAutoimmune DiseasesAzathioprineB-LymphocytesFemaleHumansMaleMiddle AgedPneumoniaRituximabThymus NeoplasmsT-LymphocytesTreatment OutcomeAutoantibodiesAzathioprineRituximabAzathioprineBronchiectasisKCNRGPneumonitisRituximabThymoma

Identifiers

PMID38954150
PMCPMC11219442

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.