Evidence map›Paper›PMID 38954116›Full record

ArticleMedical oncology (Northwood, London, England)2024

Role of ZNF334 in cervical cancer: implications for EMT reversal and tumor suppression.

Qian Li, Xiangyi Zhou, Jiayi Xiao, Yijia Gong, Xue Gong, Bianfei Shao, Jianhua Wang, Lijuan Zhao, Qi Xiong, Yue Wu and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qian Li *Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xiangyi Zhou *Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Jiayi XiaoWest China School of Medicine, Sichuan University, Chengdu Sichuan, 610065, China.
Yijia GongDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Xue GongDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Bianfei ShaoDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Jianhua WangDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Lijuan ZhaoDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Qi XiongDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yue WuDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Jun TangDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Qiyu YangDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Junying TangDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. tangjy_cqmu@sina.com.
Tingxiu XiangDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. xiangtx@cqmu.edu.cn.

Funding

Medical and Industrial Integration Project 2022CDJYGRH-002National Natural Science Foundation of China #82172619Natural Science Foundation of Chongqing Municipality CSTB2023NSCQ-MSX0386Natural Science Foundation of Chongqing Municipality CSTC2021jscx-gksb-N0023
6 · The paper itself

Abstract

Zinc-finger proteins are involved in many biological processes. However, the role of Zinc-finger protein 334 (ZNF334) in cervical cancer remains unidentified. This study showed that promoter methylation of ZNF334 was responsible for its reduced expression. ZNF334 suppressed malignant biological behaviors in cervical cancer. Notably, ZNF334 reversed the EMT process both in vitro and in vivo. RNA-seq coupled with bioinformatics analysis caught P3H3 which is upregulated by ZNF334. Dual-luciferase reporter and Chromatin immunoprecipitation assays illustrated that ZNF334 directly regulate P3H3. Knockdown of P3H3 attenuated the reversal of EMT induced by ZNF334. Additionally, ZNF334 overexpression sensitized cervical cancer cells to the cytotoxic effects of paclitaxel, cyclosporine and sunitinib. In conclusions, this study illustrated that DNA methylation-based silencing ZNF334 played a vital role in cervical cancer, by regulating P3H3 in turn affects EMT. ZNF334 has the potential to become a novel diagnostic biomarker and a potential treatment target for cervical cancer.

Indexed as

DNA MethylationEpithelial-Mesenchymal TransitionUterine Cervical NeoplasmsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHistonesHumansMiceMice, Inbred BALB CMice, NudePromoter Regions, GeneticTranscription FactorsHistonesTranscription FactorsCervical cancerEMTP3H3Transcription factorZNF334

Identifiers

PMID38954116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.