Evidence map›Paper›PMID 38954091›Full record

ArticleAnnals of surgical oncology2024

Surveillance Strategies After Primary Treatment for Patients with Invasive Lobular Carcinoma of the Breast: Method of Local Recurrence Detection After Breast-Conserving Surgery.

Elle N Clelland, Astrid Quirarte, Harriet T Rothschild, Mandeep Kaur, Firdows Mujir, Helena Record, Jasmine M Wong, Rita A Mukhtar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elle N ClellandUniversity of California, San Francisco School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1439-0532
Astrid QuirarteDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0003-9321-4808
Harriet T RothschildUniversity of California, San Francisco School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5311-2872
Mandeep KaurDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5544-5918
Firdows MujirDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0008-7882-994X
Helena RecordDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1992-3326
Jasmine M WongDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Rita A MukhtarDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA. rita.mukhtar@ucsf.edu.ORCID http://orcid.org/0000-0001-8079-7846

Funding

Identifying responders to chemotherapy in invasive lobular carcinoma of the breast: development of a multivariable clinical prediction toolK08CA256047 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUKHTAR, RITA · 2021 to 2025
$1.3M
National Cancer Institute Award K08CA256047NCI NIH HHS K08 CA256047
6 · The paper itself

Abstract

backgroundInvasive lobular carcinoma (ILC) is the second most common subtype of breast cancer. Although mammography is known to have low sensitivity for ILC, there are no data to guide the optimal surveillance after treatment. We explored surveillance strategies after breast-conserving surgery (BCS) for ILC and determined the proportion of imaging-detected recurrences versus interval cancers.

methodsFrom an institutional database of 813 women, we retrospectively identified patients who underwent BCS for stage I-III ILC and subsequently had a recurrence. We categorized patients by surveillance strategy and determined the modality of recurrence detection. Interval cancer rates for local recurrences were compared across surveillance strategies using the Chi-square test. We evaluated overall survival with the log-rank test and a Cox proportional hazards model.

resultsWe included 58 patients with ILC who had a recurrence after BCS. Of these, 22 (37.9%) had local recurrence, 27 (46.6%) had distant recurrence, and 9 (15.5%) had both local and distant recurrence. Most patients underwent routine mammographic surveillance (65.2%), with 19.6% having supplemental breast magnetic resonance imaging (MRI) and 15.2% having no surveillance. The interval cancer rate was significantly higher in the mammographic surveillance group compared with the MRI surveillance group (61.9% vs. 16.7%; p < 0.001).

conclusionIn this study of patients with recurrence after BCS for primary treatment of stage I-III ILC, we found that most local recurrences were not detected by surveillance mammography. These data support further investigation of supplemental imaging beyond mammography specifically for patients with ILC who undergo BCS.

Indexed as

Breast NeoplasmsCarcinoma, LobularMagnetic Resonance ImagingMammographyMastectomy, SegmentalNeoplasm Recurrence, LocalAdultAgedFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm InvasivenessPopulation SurveillancePrognosisRetrospective StudiesBreast cancerImagingInvasive lobular carcinomaRecurrenceSurveillance

Identifiers

PMID38954091
PMCPMC11452458

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.