Evidence map›Paper›PMID 38954037›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication.

Dhruv Gaur, Michael G Michalopulos, Keri A Drake, Jyothsna Gattineni

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dhruv GaurDivision of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA.
Michael G MichalopulosDivision of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA.
Keri A DrakeDivision of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA.
Jyothsna GattineniDivision of Pediatric Nephrology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA. Jyothsna.Gattineni@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-9404-0411

Funding

Consequences of Elevated Fibroblast Growth Factor 23 in the Presence and Absence of Kidney DiseaseR01DK118021 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GATTINENI, JYOTHSNA · 2018 to 2022
$1.6M
Wilms tumor 1 (Wt1) mutation reveals mechanisms of cell lineage crosstalk in the developing kidneyK08DK131258 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DRAKE, KERI ANNE · 2022 to 2024
$502k
NCATS NIH HHS National Center for Advancing Translational Sciences (CTSA-TPP-YR3-D-002)NIDDK NIH HHS K08 DK131258NIDDK NIH HHS K08DK131258NIDDK NIH HHS R01 DK118021NIDDK NIH HHS R01DK118021
6 · The paper itself

Abstract

While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.

Indexed as

AcetaminophenAcid-Base EquilibriumAcidosisAmino Acid Metabolism, Inborn ErrorsAnalgesics, Non-NarcoticHumansPeritoneal DialysisPyrrolidonecarboxylic AcidRenal Insufficiency, ChronicAcetaminophenAnalgesics, Non-NarcoticPyrrolidonecarboxylic AcidAcetaminophenAnion gapMetabolic acidosisPyroglutamic acidosis

Identifiers

PMID38954037
PMCPMC13380849

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.