Evidence map›Paper›PMID 38953947›Full record

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.

Yan Luo, Shengyuan Zheng, Shide Jiang, Guang Yang, Volotovski Pavel, Haoran Ji, Shujie Zhou, Yunong Bao, Wenfeng Xiao, Yusheng Li

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan LuoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shengyuan ZhengDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shide JiangThe Central Hospital of Yongzhou, Yongzhou, 425000, China.
Guang YangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Volotovski PavelRepublican Scientific and Practical Center of Traumatology and Orthopedics, 220024, Minsk, Belarus.
Haoran JiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shujie ZhouDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yunong BaoXiangya Medicine School, Central South University, Changsha, Hunan, China.
Wenfeng XiaoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiaowenfeng@csu.edu.cn.
Yusheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. liyusheng@csu.edu.cn.ORCID http://orcid.org/0000-0002-3404-0807

Funding

National Key R&D Program of China 2019YFA0111900National Natural Science Foundation of China 82072506National Natural Science Foundation of China 92268115Natural Science Foundation of Hunan Province 2022JJ70162Science and Technology Innovation Program of Hunan Province 2021RC3025
6 · The paper itself

Abstract

Our study showed that B vitamins did not have significant effect on fracture incidence, bone mineral density, and bone turnover markers. However, the research data of B vitamins on bone mineral density and bone turnover markers are limited, and more clinical trials are needed to draw sufficient conclusions. PURPOSE: The objective of this study was to identify the efficacy of B vitamin (VB) (folate, B6, and B12) supplements on fracture incidence, bone mineral density (BMD), and bone turnover markers (BTMs).

methodsA comprehensive search was performed in PubMed, MEDLINE, EMBASE, Cochrane databases, and ClinicalTrials.gov up to September 4, 2023. The risk of bias was assessed according to Cochrane Handbook and the quality of evidence was assessed according to the GRADE system. We used trial sequential analysis (TSA) to assess risk of random errors and Stata 14 to conduct sensitivity and publication bias analyses.

resultsData from 14 RCTs with 34,700 patients were extracted and analyzed. The results showed that VBs did not significantly reduce the fracture incidence (RR, 1.06; 95% CI, 0.95 - 1.18; p = 0.33; I

conclusionsAvailable evidence from RCTs does not support VBs can effectively influence osteoporotic fracture risk, BMD, and BTMs.

trial registrationPROSPERO registration number: CRD42023427508.

Indexed as

Bone DensityBone RemodelingOsteoporotic FracturesVitamin B ComplexBiomarkersDietary SupplementsFolic AcidHumansIncidenceRandomized Controlled Trials as TopicVitamin B 12Vitamin B 6BiomarkersFolic AcidVitamin B 12Vitamin B 6Vitamin B ComplexBone mineral densityBone turnover markersB vitaminsFractureMeta-analysisTrial sequential analysis

Identifiers

PMID38953947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.