Evidence map›Paper›PMID 38953857›Full record

ArticleEmerging microbes & infections2024

A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2.

Hancong Sun, Lingyun Xia, Jianhua Li, Yuanyuan Zhang, Guanying Zhang, Ping Huang, Xingxing Wang, Yue Cui, Ting Fang, Pengfei Fan and 3 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hancong SunInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Lingyun XiaCenter for Infectious Disease Research, Research Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, People's Republic of China.
Jianhua LiDepartment of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Key Laboratory of Public Health Detection and Etiological Research of Zhejiang Province, Hangzhou, Zhejiang Province, People's Republic of China.
Yuanyuan ZhangCenter for Infectious Disease Research, Research Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, People's Republic of China.
Guanying ZhangInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Ping HuangInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Xingxing WangDepartment of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Key Laboratory of Public Health Detection and Etiological Research of Zhejiang Province, Hangzhou, Zhejiang Province, People's Republic of China.
Yue CuiInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Ting FangInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Pengfei FanInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Qiang ZhouCenter for Infectious Disease Research, Research Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, People's Republic of China.
Xiangyang ChiInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Changming YuInstitute of Biotechnology, Academy of Military Medical Sciences, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 has been evolving into a large number of variants, including the highly pathogenic Delta variant, and the currently prevalent Omicron subvariants with extensive evasion capability, which raises an urgent need to develop new broad-spectrum neutralizing antibodies. Herein, we engineer two IgG-(scFv)

Indexed as

Antibodies, BispecificAntibodies, ViralEpitopesProtein DomainsAntibodies, NeutralizingAntigens, ViralCryoelectron MicroscopyHumansImmune EvasionModels, MolecularMutationNeutralization TestsProtein Structure, QuaternarySARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, BispecificAntibodies, NeutralizingAntibodies, ViralAntigens, ViralEpitopesSpike Glycoprotein, Coronavirusbispecific antibodiesCryo-EMIgG-(scFv)2Omicron subvariantsSARS-CoV-2

Identifiers

PMID38953857
PMCPMC11249148

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.