ArticleEuropean heart journal2025
Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis.
Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Association between cardiorespiratory fitness and risk of incident venous thromboembolism: a prospective cohort study.Research and practice in thrombosis and haemostasis · 2026Article
- Biological Age Acceleration and All-Cause Mortality in Moderate to Severe Aortic Valve Stenosis: A Prospective Cohort Study.JACC. Asia · 2026Article
- Metabolic dysfunction-associated fatty liver disease and risk of knee osteoarthritis: A prospective cohort study.Clinical and experimental medicine · 2026Article
- Physical activity patterns, genetic susceptibility, and incident ischemic stroke: a population-based cohort study.Frontiers in aging neuroscience · 2026Article
- Accelerated Biological Aging, Genetic Predisposition, and Incident Valvular Heart Disease.JACC. Asia · 2026Article
- Accelerated biological aging and incident degenerative valvular heart disease: Findings from 408,783 UK Biobank participants.International journal of cardiology. Heart & vasculature · 2025Article
- Sex differences in the association of wearable accelerometer-derived physical activity with coronary heart disease incidence and mortality.Nature cardiovascular research · 2025Article
- Benefits of Better Cardiovascular Health for Calcific Aortic Valve Stenosis Stratified by Polygenic Risk Score.Genomics, proteomics & bioinformatics · 2025Article
- Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study.Cardiovascular diabetology · 2025Article
- Interactions Between Sedentary Behaviour, Moderate-Vigorous Intensity Physical Activity and Acute Psychological Stress-Induced Inflammatory Responses.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Association Between Inflammatory Arthritis, Genetic Risk, and the Long-Term Risk of Degenerative Aortic Stenosis: A Prospective Cohort Study.Journal of the American Heart Association · 2025Article
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17 authors.
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Abstract
BACKGROUND AND
aimsPhysical activity has proven effective in preventing atherosclerotic cardiovascular disease, but its role in preventing degenerative valvular heart disease (VHD) remains uncertain. This study aimed to explore the dose-response association between moderate to vigorous physical activity (MVPA) volume and the risk of degenerative VHD among middle-aged adults.
methodsA full week of accelerometer-derived MVPA data from 87 248 UK Biobank participants (median age 63.3, female: 56.9%) between 2013 and 2015 were used for primary analysis. Questionnaire-derived MVPA data from 361 681 UK Biobank participants (median age 57.7, female: 52.7%) between 2006 and 2010 were used for secondary analysis. The primary outcome was the diagnosis of incident degenerative VHD, including aortic valve stenosis (AS), aortic valve regurgitation (AR), and mitral valve regurgitation (MR). The secondary outcome was VHD-related intervention or mortality.
resultsIn the accelerometer-derived MVPA cohort, 555 incident AS, 201 incident AR, and 655 incident MR occurred during a median follow-up of 8.11 years. Increased MVPA volume showed a steady decline in AS risk and subsequent AS-related intervention or mortality risk, levelling off beyond approximately 300 min/week. In contrast, its association with AR or MR incidence was less apparent. The adjusted rates of AS incidence (95% confidence interval) across MVPA quartiles (Q1-Q4) were 11.60 (10.20, 13.20), 7.82 (6.63, 9.23), 5.74 (4.67, 7.08), and 5.91 (4.73, 7.39) per 10 000 person-years. The corresponding adjusted rates of AS-related intervention or mortality were 4.37 (3.52, 5.43), 2.81 (2.13, 3.71), 1.93 (1.36, 2.75), and 2.14 (1.50, 3.06) per 10 000 person-years, respectively. Aortic valve stenosis risk reduction was also observed with questionnaire-based MVPA data [adjusted absolute difference Q4 vs. Q1: AS incidence, -1.41 (-.67, -2.14) per 10 000 person-years; AS-related intervention or mortality, -.38 (-.04, -.88) per 10 000 person-years]. The beneficial association remained consistent in high-risk populations for AS, including patients with hypertension, obesity, dyslipidaemia, and chronic kidney disease.
conclusionsHigher MVPA volume was associated with a lower risk of developing AS and subsequent AS-related intervention or mortality. Future research needs to validate these findings in diverse populations with longer durations and repeated periods of activity monitoring.
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