Evidence map›Paper›PMID 38953683›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024

Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients.

Trevor S Johnston, Camille Hage, Aura T Abedon, Snigdha Panda, Jennifer L Alejo, Yolanda Eby, Dorry L Segev, Aaron A R Tobian, Andrea L Cox, William A Werbel and 1 more

Abstract read
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In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Trevor S JohnstonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8662-541X
Camille HageDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6652-0725
Aura T AbedonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8083-6964
Snigdha PandaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jennifer L AlejoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3137-9271
Yolanda EbyDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2905-2408
Dorry L SegevDepartment of Surgery, NYU Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-1924-4801
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0517-3766
Andrea L CoxDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9331-2462
William A WerbelDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2943-5895
Andrew H KarabaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2785-317X

Funding

HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
Virology Resource CoreU54CA260492 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, SABRA L. · 2020 to 2024
$10.4M
Clinical and Laboratory Research Training for Gastrointestinal SurgeonsT32DK007713 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DAVID J HACKAM · 1996 to 2026
$5.2M
Modulation of Herpes Simplex Virus Pathogenesis by Leucine Rich Repeat Kinase 2K08AI156021 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARABA, ANDREW HOOVER · 2021 to 2025
$994k
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
The Landscape of Serious Infections following Kidney Transplantation in People Living with HIVK23AI157893 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WERBEL, WILLIAM · 2021 to 2025
$847k
Ben-Dov familyNational Institute of Allergy and Infectious Diseases K24AI144954NCI NIH HHS U54 CA260492NCI NIH HHS U54CA260492NIAID NIH HHS K08 AI156021NIAID NIH HHS K23 AI157893NIAID NIH HHS K24 AI144954NIAID NIH HHS U01 AI138897NIDDK NIH HHS 5T32DK007713NIDDK NIH HHS T32 DK007713NIHTrokhan Patterson family
6 · The paper itself

Abstract

Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesImmunization, SecondaryOrgan TransplantationSARS-CoV-2Transplant Recipients2019-nCoV Vaccine mRNA-1273AdultAgedFemaleHumansMaleMiddle AgedVaccination2019-nCoV Vaccine mRNA-1273Antibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesCOVID-19immunocompromised hostSARS-CoV-2vaccines

Identifiers

PMID38953683
PMCPMC11426267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.