Evidence map›Paper›PMID 38953638›Full record

ArticlemBio2024

Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection.

Jenai Quan, Qing Fan, Lacy M Simons, Samuel N Smukowski, Caitlin Pegg, Richard Longnecker, Jeffrey N Savas, Judd F Hultquist, Gregory A Smith

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenai QuanDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-2311-249X
Qing FanDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-9673-5575
Lacy M SimonsDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Samuel N SmukowskiDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Caitlin PeggDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Richard LongneckerDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-7175-6217
Jeffrey N SavasDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Judd F HultquistDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Gregory A SmithDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-9644-8472

Funding

Virology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sahera Dirajlal-Fargo · 2015 to 2026
$38.4M
TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
Virus-host interactions governing alpha-herpesvirus genome delivery and neuroinvasionR01AI148780 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PICKARD, GARY EDWARD, SAVAS, JEFFREY NICHOLAS · 2020 to 2024
$2.5M
Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration HubS10OD032464 · OD · NORTHWESTERN UNIVERSITY · PI SAVAS, JEFFREY NICHOLAS · 2023 to 2023
$1.3M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI14878HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI148780HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007476NIAID NIH HHS P30 AI117943NIAID NIH HHS R01 AI148780NIAID NIH HHS T32 AI007476NIH HHS S10 OD032464Third Coast Center for AIDS Research (TC CFAR) P30AI117943
6 · The paper itself

Abstract

Neurotropic alphaherpesviruses, including herpes simplex virus type 1 and pseudorabies virus, establish a lifelong presence within the peripheral nervous system of their mammalian hosts. Upon entering cells, two conserved tegument proteins, pUL36 and pUL37, traffic DNA-containing capsids to nuclei. These proteins support long-distance retrograde axonal transport and invasion of the nervous system

Indexed as

BiotinAlphaherpesvirinaeAnimalsCell LineCRISPR-Cas SystemsEpithelial CellsHerpesvirus 1, HumanHerpesvirus 1, SuidHost-Pathogen InteractionsHumansZyxinBiotinZyxinBioID2CRISPRcytoskeletonHSVproximity labelingPRVpUL36pUL37tegumentzyxin

Identifiers

PMID38953638
PMCPMC11323796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.