Evidence map›Paper›PMID 38953632›Full record

ArticlemBio2024

Multiple levels of transcriptional regulation control glycolate metabolism in

Lennart Schada von Borzyskowski, Lucas Hermann, Katharina Kremer, Sebastian Barthel, Bianca Pommerenke, Timo Glatter, Nicole Paczia, Erhard Bremer, Tobias J Erb

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Synthetic biology (Oxford, England) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lennart Schada von BorzyskowskiDepartment of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.ORCID 0000-0003-2952-4572
Lucas HermannLaboratory for Microbiology, Department of Biology, Philipps-University Marburg, Marburg, Germany.
Katharina KremerDepartment of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Sebastian BarthelDepartment of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Bianca PommerenkeDepartment of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Timo GlatterFacility for Mass Spectrometry and Proteomics, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Nicole PacziaFacility for Metabolomics and Small Molecule Mass Spectrometry, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Erhard BremerLaboratory for Microbiology, Department of Biology, Philipps-University Marburg, Marburg, Germany.ORCID 0000-0002-2225-7005
Tobias J ErbDepartment of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.ORCID 0000-0003-3685-0894

Funding

Deutsche Forschungsgemeinschaft (DFG) 192445154Max-Planck-Gesellschaft (MPG)
6 · The paper itself

Abstract

The hydroxyacid glycolate is a highly abundant carbon source in the environment. Glycolate is produced by unicellular photosynthetic organisms and excreted at petagram scales to the environment, where it serves as growth substrate for heterotrophic bacteria. In microbial metabolism, glycolate is first oxidized to glyoxylate by the enzyme glycolate oxidase. The recently described β-hydroxyaspartate cycle (BHAC) subsequently mediates the carbon-neutral assimilation of glyoxylate into central metabolism in ubiquitous Alpha- and Gammaproteobacteria. Although the reaction sequence of the BHAC was elucidated in

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialGlycolatesParacoccus denitrificansAlcohol OxidoreductasesGlyoxylatesMetabolic Networks and PathwaysMultigene FamilyTranscription FactorsAlcohol OxidoreductasesBacterial ProteinsGlycolatesglycolic acidGlyoxylatesglyoxylic acidTranscription FactorsAlphaproteobacteriacarbon metabolismglycolatetranscriptional regulation

Identifiers

PMID38953632
PMCPMC11323563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.