Evidence map›Paper›PMID 38953550›Full record

ArticleBJU international2024

Association of Genomic Prostate Score at positive margin with recurrence after radical prostatectomy.

Sanaz Nourmohammadi Abadchi, Daniela C Salles, Cynthia Flannery, Varun Sama, Frederick L Baehner, Joao P Zambon, Adrianna A Mendes, Lia DePaula Oliveira, Misop Han, Yuezhou Jing and 3 more

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In one paragraph

Article in BJU international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sanaz Nourmohammadi AbadchiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2167-7793
Daniela C SallesDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cynthia FlanneryExact Biosciences, Madison, WI, USA.
Varun SamaExact Biosciences, Madison, WI, USA.
Frederick L BaehnerExact Biosciences, Madison, WI, USA.ORCID 0000-0001-6883-1212
Joao P ZambonMDX Health Corporation, Irvine, CA, USA.
Adrianna A MendesDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lia DePaula OliveiraDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0005-5274-8453
Misop HanMDX Health Corporation, Irvine, CA, USA.
Yuezhou JingDepartment of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alan W PartinDepartment of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bruce J TrockDepartment of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tamara L LotanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973Sturm Family Foundation
6 · The paper itself

Abstract

objectivesTo evaluate the utility of the 17-gene Genomic Prostate Score® (GPS; MDxHealth, Irvine, CA, USA) performed on prostate cancer at the positive margin of the radical prostatectomy (RP) for its association with risk of subsequent biochemical recurrence (BCR). PATIENTS AND

methodsWe designed a case-cohort for the outcome of BCR, selecting 223 from a cohort of 813 RP patients treated at Johns Hopkins from 2008 to 2017 with positive margins and available clinical data; of these, 213 had available tissue and clinical data. RNA was isolated from formalin-fixed paraffin-embedded tumour tissue adjacent to the positive surgical margin and the GPS was evaluable in 203 of these patients with a score ranging from 0 to 100, with higher scores indicating higher risk. All patients underwent RP with or without adjuvant radiation therapy (ART). The statistical analysis employed Cox proportional hazards regression models for outcome of BCR weighted for case-cohort design.

resultsIn univariable analysis, every 20-unit increase in the GPS was associated with a nearly threefold increase in risk of BCR (hazard ratio [HR] per 20 units 2.82, P < 0.001). In a multivariable Cox model adjusted for age, race, Cancer of the Prostate Risk Assessment Postsurgical score, Grade Group at the positive margin, and ART, the GPS was significantly associated with BCR (HR 1.56 per 20 units; 95% confidence interval 1.11-2.19; P = 0.011). The study is limited by its retrospective and single institution design.

conclusionsThe GPS at the positive surgical margin could help stratify prognosis and inform clinical decision-making regarding adjuvant therapy after RP.

Indexed as

Margins of ExcisionNeoplasm Recurrence, LocalProstatectomyProstatic NeoplasmsAgedHumansMaleMiddle AgedRetrospective StudiesRisk Assessmentbiochemical recurrenceGenomic Prostate Scorepositive surgical marginprostate cancerradiation therapy

Identifiers

PMID38953550
PMCPMC11977573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.