Evidence map›Paper›PMID 38953369›Full record

ArticleApplied and environmental microbiology2024

ROK family regulator NagC promotes prodigiosin biosynthesis independent of

Weijie Liu, Rui Shi, Ying Zhang, Chenchen Li, Xuge Zhou, Marcus Sepo Jensen, Jing Yang, Siyi Zhao, Jiawen Liu, Jingrong Zhu and 2 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Weijie Liu *School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.ORCID 0000-0002-7152-6013
Rui Shi *School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Ying Zhang *School of Life Science, Beijing Institute of Technology, Beijing, China.ORCID 0000-0002-9387-3411
Chenchen LiSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Xuge ZhouSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Marcus Sepo JensenSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Jing YangSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Siyi ZhaoSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Jiawen LiuSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Jingrong ZhuSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
Cong LiuSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.ORCID 0000-0001-5749-0432
Di SunSchool of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.ORCID 0000-0001-9980-5439

Funding

Jiangsu Agricultural Science and Technology Innovation Fund (JASTIF) CX(22)3125JST | Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation) BK20210920JST | Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation) BK20231350MOST | National Natural Science Foundation of China (NSFC) 32270119MOST | National Natural Science Foundation of China (NSFC) 32370023, 31970036MOST | National Natural Science Foundation of China (NSFC) 32370583, 31900401| Natural Science Foundation of Xuzhou Municipality (Xuzhou Natural Science Foundation) KC23301Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)Space Application System of China Manned Space Program
6 · The paper itself

Abstract

IMPORTANCE: The ROK family transcription factor NagC is an important global regulator in the γ-proteobacteria. A large number of genes involved in the transport and metabolism of sugars, as well as those associated with biofilm formation and pathogenicity, are regulated by NagC. In all of these regulations, the transcriptional regulatory activity of NagC responds to the supply of GlcNAc in the environment. Here, we found for the first time that NagC can regulate antibiotic biosynthesis, whose transcriptional regulatory activity is independent of GlcNAc. This suggests that NagC may respond to more signals and regulate more physiological processes in Gram-negative bacteria.

Indexed as

AcetylglucosamineBacterial ProteinsGene Expression Regulation, BacterialProdigiosinSerratiaOperonTranscription FactorsAcetylglucosamineBacterial ProteinsProdigiosinTranscription FactorsGlcNAcNagCprodigiosin biosynthesisSerratia sp. ATCC 39006transcriptional regulation

Identifiers

PMID38953369
PMCPMC11267903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.