Evidence map›Paper›PMID 38953356›Full record

ArticlemBio2024

Variations in candidalysin amino acid sequence influence toxicity and host responses.

Don N Wickramasinghe, Claire M Lyon, Sejeong Lee, Olivia W Hepworth, Emily L Priest, Corinne Maufrais, Adam P Ryan, Emmanuelle Permal, Derek Sullivan, Brenda A McManus and 5 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Phenotypic and genotypic analysis ofInfection and immunity · 2026
    Article
  3. Review
  4. Article
  5. Hemolytic Activity of VaginalPathogens (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Microorganisms · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Don N WickramasingheCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.
Claire M LyonCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.
Sejeong LeeCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0001-8617-3436
Olivia W HepworthCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.
Emily L PriestCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.
Corinne MaufraisInstitut Pasteur, Université Paris Cité, INRAe USC 2019, Unité Biologie et Pathogénicité Fongiques, Paris, France.
Adam P RyanSchool of Biomedical and Biomolecular Science and UCD Conway Institute of Biomolecular and Biomedical Research, Conway Institute, University College Dublin, Dublin, Ireland.
Emmanuelle PermalInstitut Pasteur, Université Paris Cité, INRAe USC 2019, Unité Biologie et Pathogénicité Fongiques, Paris, France.
Derek SullivanDivision of Oral Biosciences, Dublin Dental University Hospital, and School of Dental Science, Trinity College Dublin, Dublin, Ireland.
Brenda A McManusDivision of Oral Biosciences, Dublin Dental University Hospital, and School of Dental Science, Trinity College Dublin, Dublin, Ireland.
Bernhard HubeDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (HKI), Jena, Germany.ORCID 0000-0002-6028-0425
Geraldine ButlerSchool of Biomedical and Biomolecular Science and UCD Conway Institute of Biomolecular and Biomedical Research, Conway Institute, University College Dublin, Dublin, Ireland.ORCID 0000-0002-1770-5301
Christophe d'EnfertInstitut Pasteur, Université Paris Cité, INRAe USC 2019, Unité Biologie et Pathogénicité Fongiques, Paris, France.ORCID 0000-0002-6235-3886
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0002-8072-7917
Jonathan P RichardsonCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0001-9638-2725

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
Agence Nationale de la Recherche (ANR) ANR-10-LABX-62-IBEIDDeutsche Forschungsgemeinschaft (DFG) FungiNetFoDOCs PhD StudentshipHHS | National Institutes of Health (NIH) R37-DE022550Irish Research Council (An Chomhairle um Thaighde in Éirinn)MRC DTP (MR/W006820/1)NIDCR NIH HHS R37 DE022550Science Foundation Ireland (SFI) 19/FFP/6668The Swiss National Science Foundation Sinergia CRSII5_173863 /1Wellcome TrustWellcome Trust (WT) 214229_Z_18_Z
6 · The paper itself

Abstract

IMPORTANCE: Fungal infections are a significant burden to health. Candidalysin is a toxin produced by

Indexed as

Candida albicansEpithelial CellsFungal ProteinsAmino Acid SequenceCandidaCandida tropicalisCandidiasisGenetic VariationHumansECE1 protein, Candida albicansFungal ProteinsCandidacandidalysinepithelialfungustoxin

Identifiers

PMID38953356
PMCPMC11323794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.