Evidence map›Paper›PMID 38953329›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Light-Activated In Situ Vaccine with Enhanced Cytotoxic T Lymphocyte Infiltration and Function for Potent Cancer Immunotherapy.

Xian An, Zhuang Chen, Yi Luo, Peng Yang, Zuo Yang, Tiannan Ji, Yajing Chi, Shuyuan Wang, Ruili Zhang, Zhongliang Wang and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xian AnMedical School of Chinese PLA & Department of Oncology, Chinese PLA General Hospital, Beijing, 100193, P. R. China.
Zhuang ChenLab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuro-imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, P. R. China.
Yi LuoLab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuro-imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, P. R. China.
Peng YangLab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuro-imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, P. R. China.
Zuo YangLab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuro-imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, P. R. China.
Tiannan JiDepartment of Emergency, The Fifth Medical Center of PLA General Hospital, Beijing, 100193, P. R. China.
Yajing ChiSchool of Medicine, Nankai University, Tianjin, 300071, P. R. China.
Shuyuan WangMedical School of Chinese PLA & Department of Oncology, Chinese PLA General Hospital, Beijing, 100193, P. R. China.
Ruili ZhangLab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuro-imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, P. R. China.
Zhongliang WangLab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuro-imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, P. R. China.ORCID 0000-0001-9388-149X
Jianxiong LiMedical School of Chinese PLA & Department of Oncology, Chinese PLA General Hospital, Beijing, 100193, P. R. China.

Funding

Innovation Capability Support Program of Shaanxi 2022TD-52Key Research and Development Program of Shaanxi 2024SF-YBXM-126National Key Research and Development Program of China 2022YFB3203800National Natural Science Foundation of China 82272159National Natural Science Foundation of China 82373515Open Project Program of the State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers CBSKL2022ZDKF14Shaanxi Fundamental Science Research Project for Chemistry and Biology 23JHZ005
6 · The paper itself

Abstract

In situ cancer vaccination is an attractive strategy that stimulates protective antitumor immunity. Cytotoxic T lymphocytes (CTLs) are major mediators of the adaptive immune defenses, with critical roles in antitumor immune response and establishing immune memory, and are consequently extremely important for in situ vaccines to generate systemic and lasting antitumor efficacy. However, the dense extracellular matrix and hypoxia in solid tumors severely impede the infiltration and function of CTLs, ultimately compromising the efficacy of in situ cancer vaccines. To address this issue, a robust in situ cancer vaccine, Au@MnO

Indexed as

Cancer VaccinesGoldImmunotherapyT-Lymphocytes, CytotoxicTumor MicroenvironmentAnimalsCell Line, TumorDisease Models, AnimalHumansLightManganese CompoundsMetal NanoparticlesMiceNeoplasmsOxidesCancer VaccinesGoldManganese Compoundsmanganese dioxideOxidescGAS‐STING pathwaycytotoxic T lymphocytesimmunogenic cell deathin situ cancer vaccinetumor microenvironment

Identifiers

PMID38953329
PMCPMC11434106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.