Evidence map›Paper›PMID 38953319›Full record

ArticlemSystems2024

Machine learning-based classification reveals distinct clusters of non-coding genomic allelic variations associated with Erm-mediated antibiotic resistance.

Yongjun Tan, Alexandre Le Scornet, Mee-Ngan Frances Yap, Dapeng Zhang

Abstract read
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Highly Conserved Genetic Factors RegulatingJournal of microbiology and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yongjun TanDepartment of Biology, College of Arts and Sciences, Saint Louis University, St. Louis, Missouri, USA.ORCID 0009-0006-2361-1498
Alexandre Le ScornetDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-7572-077X
Mee-Ngan Frances YapDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-4213-4050
Dapeng ZhangDepartment of Biology, College of Arts and Sciences, Saint Louis University, St. Louis, Missouri, USA.ORCID 0000-0001-8535-7620

Funding

Regulation and function of bacterial hibernating 100S ribosomeR01GM121359 · NIGMS · SAINT LOUIS UNIVERSITY · PI YAP, M.-N. FRANCES · 2017 to 2025
$3.2M
Evolution and consequences of multidrug resistant ribosomeR01AI150986 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YAP, M.-N. FRANCES · 2020 to 2024
$2.3M
HHS | National Institutes of Health (NIH) R01AI150986NIAID NIH HHS R01 AI150986NIGMS NIH HHS R01 GM121359U.S. Department of Defense (DOD) W81XWH-18-1-0122
6 · The paper itself

Abstract

The erythromycin resistance RNA methyltransferase ( IMPORTANCE: Antibiotic resistance (AR) poses a global health threat as the efficacy of available antibiotics has rapidly eroded due to the widespread transmission of AR genes. Using Erm-dependent MLS resistance as a model, this study highlights the significance of non-coding genomic allelic variations. Through a comprehensive analysis of upstream regulatory elements within the

Indexed as

AllelesAnti-Bacterial AgentsMachine LearningMethyltransferasesBacterial ProteinsDrug Resistance, BacterialErythromycinGenetic VariationNucleic Acid ConformationAnti-Bacterial AgentsBacterial ProteinsErythromycinMethyltransferasesantibiotic resistanceemergence and evolution of ARermBMLS phenotype predictionnon-coding regulatory elements

Identifiers

PMID38953319
PMCPMC11264731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.