Evidence map›Paper›PMID 38952980›Full record

ArticlePeerJ2024

Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer.

Zhaohong Wang, Hui Chen, Xufan Cai, Heqi Bu, Shengzhang Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhaohong WangDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China.
Hui ChenDepartment of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xufan CaiZhejiang Chinese Medical University, Hanzhou, China.
Heqi BuDepartment of Surgery, Tongde Hospital of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China.
Shengzhang LinDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, China.

Funding

Natural Science Foundation of Zhejiang
6 · The paper itself

Abstract

Background: Andrographolide (Andro), an extract of Methods: The cytotoxic potential of Andro and underlying mechanism towards PC cells was investigated through Results: Andro demonstrated potent anti-proliferative effects on PC cells and induced apoptosis, both Conclusion: Our study indicated that ROS accumulation induced by the DJ-1 reduction played a key role in Andro-mediated PC cell inhibition. Furthermore, the protective autophagy induced by the Andro in PC cells is a mechanism that needs to be addressed in future studies.

Indexed as

ApoptosisAutophagyDiterpenesPancreatic NeoplasmsProtein Deglycase DJ-1Reactive Oxygen SpeciesAnimalsCell Line, TumorHumansMiceMice, NudeXenograft Model Antitumor AssaysandrographolideDiterpenesPARK7 protein, humanProtein Deglycase DJ-1Reactive Oxygen SpeciesAndrographolideDJ-1Pancreatic cancerProtective autophagyReactive oxygen species

Identifiers

PMID38952980
PMCPMC11216212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.