Evidence map›Paper›PMID 38952968›Full record

ArticlePeerJ2024

Positive peritoneal lavage fluid cytology based on isolation by size of epithelial tumor cells indicates a high risk of peritoneal metastasis.

Ying Xuan, Qizhong Gao, Chenhu Wang, Dongyan Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying Xuan *Jiangnan University, Wuxi School of Medicine, Wuxi, China.
Qizhong Gao *Affiliated Hospital of Jiangnan University, Department of Oncology, Wuxi, China.
Chenhu WangAffiliated Hospital of Jiangnan University, Department of Oncology, Wuxi, China.
Dongyan CaiAffiliated Hospital of Jiangnan University, Department of Oncology, Wuxi, China.

Funding

Top Wuxi Health Committee Program
6 · The paper itself

Abstract

Background: Peritoneal metastasis (PM) is the most prevalent type of metastasis in patients with gastric cancer (GC) and has an extremely poor prognosis. The detection of free cancer cells (FCCs) in the peritoneal cavity has been demonstrated to be one of the worst prognostic factors for GC. However, there is a lack of sensitive detection methods for FCCs in the peritoneal cavity. This study aimed to use a new peritoneal lavage fluid cytology examination to detect FCCs in patients with GC, and to explore its clinical significance on diagnosing of occult peritoneal metastasis (OPM) and prognosis. Methods: Peritoneal lavage fluid from 50 patients with GC was obtained and processed Results: Using a combination of the ISET platform and immunofluorescence-FISH, the detection of FCCs was higher than that by light microscopy (24.0% Conclusion: The ISET platform highly enriched nucleated cells from peritoneal lavage fluid, and indicators comprising EpCAM, CEP8, and CEP17 confirmed the diagnosis of FCCs. As a potential detection method, it offers an opportunity for early intervention of OPM and an extension of patient survival.

Indexed as

In Situ Hybridization, FluorescencePeritoneal LavagePeritoneal NeoplasmsStomach NeoplasmsAdultAgedAscitic FluidCytodiagnosisEpithelial Cell Adhesion MoleculeFemaleHumansMaleMiddle AgedNeoplastic Cells, CirculatingPrognosisEpithelial Cell Adhesion MoleculeFree cancer cellsGastric cancerIsolation by size of epithelial tumor cells (ISET)Occult peritoneal metastasisPeritoneal metastasisPrognosis

Identifiers

PMID38952968
PMCPMC11216200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.