Hypervalent iodine-catalyzed amide and alkene coupling enabled by lithium salt activation.

Akanksha Chhikara, Fan Wu, Navdeep Kaur, Prabagar Baskaran, Alex M Nguyen, Zhichang Yin, Anthony H Pham, Wei Li

Abstract read

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Article in Beilstein journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Akanksha ChhikaraDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.

Fan WuDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.

Navdeep KaurDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.ORCID https://orcid.org/0009-0009-5200-5106

Prabagar BaskaranDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.

Alex M NguyenDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.

Zhichang YinDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.

Anthony H PhamDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.

Wei LiDepartment of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.ORCID https://orcid.org/0000-0001-8524-217X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypervalent iodine catalysis has been widely utilized in olefin functionalization reactions. Intermolecularly, the regioselective addition of two distinct nucleophiles across the olefin is a challenging process in hypervalent iodine catalysis. We introduce here a unique strategy using simple lithium salts for hypervalent iodine catalyst activation. The activated hypervalent iodine catalyst allows the intermolecular coupling of soft nucleophiles such as amides onto electronically activated olefins with high regioselectivity.

Indexed as

amide couplinghypervalent iodine catalysislithium salt activationolefin oxyaminationoxazoline

Identifiers

PMID38952958

DOI10.3762/bjoc.20.122

PMCPMC11216091

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