Evidence map›Paper›PMID 38952568›Full record

ArticleAdvanced functional materials2024

Dissecting the Interplay Mechanism among Process Parameters toward the Biofabrication of High-Quality Shapes in Embedded Bioprinting.

Yang Wu, Xue Yang, Deepak Gupta, Mecit Altan Alioglu, Minghao Qin, Veli Ozbolat, Yao Li, Ibrahim T Ozbolat

Abstract read
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. 3D-bioprinting for joint regeneration.Frontiers in bioengineering and biotechnology · 2026
    Review
  4. Article
  5. Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels.bioRxiv : the preprint server for biology · 2025
    Article
  6. 3D Printing of Air.Research square · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang WuSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, China.
Xue YangSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, China.
Deepak GuptaThe Huck Institutes of the Life Sciences, Penn State University University Park, PA 16802, USA.
Mecit Altan AliogluThe Huck Institutes of the Life Sciences, Penn State University University Park, PA 16802, USA.
Minghao QinSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, China.
Veli OzbolatBiotechnology Research and Application Center, Cukurova University, Adana 01130, Turkey.
Yao LiSchool of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, China.
Ibrahim T OzbolatThe Huck Institutes of the Life Sciences, Penn State University University Park, PA 16802, USA.

Funding

Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionR01DE028614 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI OZBOLAT, IBRAHIM · 2020 to 2024
$2.8M
High-throughput Spheroid Bioprinting Technology for Scalable Fabrication of TissuesR01EB034566 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat · 2023 to 2026
$2.2M
NIBIB NIH HHS R01 EB034566NIDCR NIH HHS R01 DE028614
6 · The paper itself

Abstract

Embedded bioprinting overcomes the barriers associated with the conventional extrusion-based bioprinting process as it enables the direct deposition of bioinks in 3D inside a support bath by providing in situ self-support for deposited bioinks during bioprinting to prevent their collapse and deformation. Embedded bioprinting improves the shape quality of bioprinted constructs made up of soft materials and low-viscosity bioinks, leading to a promising strategy for better anatomical mimicry of tissues or organs. Herein, the interplay mechanism among the printing process parameters toward improved shape quality is critically reviewed. The impact of material properties of the support bath and bioink, printing conditions, cross-linking mechanisms, and post-printing treatment methods, on the printing fidelity, stability, and resolution of the structures is meticulously dissected and thoroughly discussed. Further, the potential scope and applications of this technology in the fields of bioprinting and regenerative medicine are presented. Finally, outstanding challenges and opportunities of embedded bioprinting as well as its promise for fabricating functional solid organs in the future are discussed.

Indexed as

embedded bioprintingprint qualityprint stabilityresolutionsupport bath

Identifiers

PMID38952568
PMCPMC11216718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.