ArticlePakistan journal of medical sciences2024
Clinical analysis of the effect of helicobacter pylori infection on immune function in children with peptic ulcer.
Article in Pakistan journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Efficacy of a family systems theory-based integrated care protocol for children with helicobacter pylori-associated gastritis.Pakistan journal of medical sciences · 2026Article
- Clinical efficacy of antibacterial drugs combined with Proton Pump Inhibitors and Bismuth in the treatment of Helicobacter Pylori-infected Peptic Ulcer.Pakistan journal of medical sciences · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
Objective: To study whether children with peptic ulcer would have abnormalities in cellular and humoral immune functions, and whether Helicobacter pylori (Hp) infection would affect the immune function of children with peptic ulcer. Methods: This is a retrospective study. The subjects of study were 72 children with diagnosed and cured peptic ulcer (ulcer group), and 50 healthy children with physical examination (control group) at Baoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University from June 2020 to December 2022. Further detection was conducted on T lymphocyte subsets (CD3+, CD4+, CD8+, and CD4+/CD8+ ratio) and immunoglobulin levels. Results: Of the 72 children with peptic ulcer, 53(73.6%) were positive for Hp (Hp-positive group) and 19 (26.4%) were negative (Hp-negative group). The levels of CD3 Conclusion: Hp infection can induce the elevation of T lymphocyte subsets. The development of peptic ulcer has an intimate association with the disorder of cellular and humoral immune functions.
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