ArticleFrontiers in neurology2024
Cognitive safety of focused ultrasound thalamotomy for tremor: 1-year follow-up results of the COGNIFUS part 2 study.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single-Centre Cohort and Systematic Review With Meta-Analysis.European journal of neurology · 2026Pooled it
- Clinical outcomes at 6 months after MRgFUS thalamotomy in Parkinson's disease: a large longitudinal cohort study.Journal of neurology · 2026Observational
- Similar DTI-ALPS metrics in Parkinson's disease and essential tremor: a cross-sectional comparative analysis.Neuroradiology · 2026Article
- The Results of a 12-Month Open-Label Follow-Up Study with MRI Monitoring of Patients with Parkinson's Disease After MRI-Guided FUS.Journal of clinical medicine · 2025Article
- MRI-Guided Focused Ultrasound in Parkinson's Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review.Journal of movement disorders · 2025Article
- High Intensity Focused Ultrasound - Longitudinal Data on Efficacy and Safety.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Review
- Radiomic signatures from postprocedural MRI thalamotomy lesion can predict long-term clinical outcome in patients with tremor after MRgFUS: a pilot study.Frontiers in radiology · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In the COGNitive in Focused UltraSound (COGNIFUS) study, we examined the 6-month cognitive outcomes of patients undergoing MRgFUS thalamotomy. This study endorsed the safety profile of the procedure in terms of cognitive functions that cannot be evaluated in real-time during the procedure unlike other aspects. The aim of the COGNIFUS Part 2 study was to investigate the cognitive trajectory of MRgFUS patients over a 1-year period, in order to confirm long-term safety and satisfaction. Methods: We prospectively evaluated the cognitive and neurobehavioral profile of patients with essential tremor (ET) or Parkinson's Disease (PD) related tremor undergoing MRgFUS thalamotomy at 1 year-follow-up following the treatment. Results: The sample consists of 50 patients (male 76%; mean age ± SD 69.0 ± 8.56; mean disease duration ± SD 12.13 ± 12.59; ET 28, PD 22 patients). A significant improvement was detected at the 1 year-follow-up assessment in anxiety and mood feelings (Hamilton Anxiety rating scale 5.66 ± 5.02 vs. 2.69 ± 3.76, Conclusion: Our study supports the long-term efficacy and cognitive safety of MRgFUS treatment for ET and PD.
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