Evidence map›Paper›PMID 38952057›Full record

ArticleJournal of applied clinical medical physics2024

Characterization of a commercial plastic scintillator for electron FLASH dosimetry.

Kyuhak Oh, Megan A Hyun, Kyle J Gallagher, Ying Yan, Sumin Zhou

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyuhak OhUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Megan A HyunUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.
Kyle J GallagherUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0003-3053-6765
Ying YanUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-3546-3991
Sumin ZhouUniversity of Nebraska Medical Center, Omaha, Nebraska, USA.

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PHILIBERT, INGRID · 2016 to 2025
$42.8M
PR55-alpha controlled PP2A in the regulation of the Hippo/YAP pathwayR01GM143329 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI YAN, YING · 2021 to 2024
$1.3M
NIGMSNIGMS NIH HHS R01 GM143329NIGMS NIH HHS U54 GM115458NIH HHS 5U54GM115458University of Nebraska Collaboration Initiative
6 · The paper itself

Abstract

purposeThis study investigated the potential of a commercially available plastic scintillator, the Exradin W2, as a real-time dosimeter for ultra-high-dose-rate (UHDR) electron beams. This work aimed to characterize this system's performance under UHDR conditions and addressed limitations inherent to other conventional dosimetry systems. METHODS AND MATERIALS: We assessed the W2's performance as a UHDR electron dosimeter using a 16 MeV UHDR electron beam from the FLASH research extension (FLEX) system. Additionally, the vendor provided a beta firmware upgrade to better handle the processing of the high signal generated in the UHDR environment. We evaluated the W2 regarding dose-per-pulse, pulse repetition rate, charge versus distance, and pulse linearity. Absorbed dose measurements were compared against those from a plane-parallel ionization chamber, optically stimulated luminescent dosimeters and radiochromic film.

resultsWe observed that the 1 × 1 mm W2 scintillator with the MAX SD was more suitable for UHDR dosimetry compared to the 1 × 3 mm W2 scintillator, capable of matching film measurements within 2% accuracy for dose-per-pulse up to 3.6 Gy/pulse. The W2 accurately ascertained the inverse square relationship regarding charge versus virtual source distance with R

conclusionsThis study tested a commercial plastic scintillator detector in a UHDR electron beam, paving the way for its potential use as a real-time, patient-specific dosimetry tool for future FLASH radiotherapy treatments. Further research is warranted to test and improve the signal processing of the W2 dosimetry system to accurately measure in UHDR environments using exceedingly high dose-per-pulse and pulse numbers.

Indexed as

ElectronsPlasticsScintillation CountingHumansParticle AcceleratorsPhantoms, ImagingRadiometryRadiotherapy DosagePlasticsdosimetryelectron ultra‐high dose rate (eFLASH)FLASH research extension (FLEX)plastic scintillator

Identifiers

PMID38952057
PMCPMC11302813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.