Evidence map›Paper›PMID 38952042›Full record

ArticleAnimal models and experimental medicine2025

Endogenous Fe

Zhongxiong Fan, Guoyu Xia, Qingluo Wang, Shiduan Chen, Jianmin Li, Zhenqing Hou, Ziwen Jiang, Juan Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Endogenous FeAnimal models and experimental medicine · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhongxiong FanSchool of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, China.ORCID 0000-0001-5751-9530
Guoyu XiaSchool of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, China.
Qingluo WangSchool of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, China.
Shiduan ChenCollege of Materials, Xiamen University, Xiamen, China.
Jianmin LiSchool of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, China.
Zhenqing HouSchool of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi, China.ORCID 0000-0002-5537-075X
Ziwen JiangDepartment of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Juan FengDepartment of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China.

Funding

Autonomous Region universities basic research funds research projects-cultivation projects XJEDU2023P017Key research and development program in Xinjiang Uygur Autonomous Region 2023B02030Key research and development program in Xinjiang Uygur Autonomous Region 2023B02030-1National Natural Science Foundation of China 82000152Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01C698Xinjiang Uygur Autonomous Region Tianchi Talent Introduction Program-Young Doctor 51052300514
6 · The paper itself

Abstract

backgroundArtesunate (ASA) acts as an •O₂

methodsASA-hyaluronic acid (HA) conjugates were formed from hydrophobic ASA and hydrophilic HA by an esterification reaction first, and then self-targeting nanomicelles (NM) were developed using the fact that the amphiphilic conjugates of ASA and HA are capable of self-assembling in aqueous environments.

resultsThese ASA-HA NMs utilize CD44 receptor-mediated transcytosis to greatly enhance uptake by breast cancer cells. Subsequently, endogenous Fe

conclusionsSelf-targeting NMs represent a promising strategy for enhancing ASA-based treatments, leveraging clinically approved drugs to expedite drug development and clinical research in oncology.

Indexed as

IronMicellesOxidative StressAnimalsAntineoplastic AgentsArtesunateBreast NeoplasmsCell Line, TumorDrug Delivery SystemsFemaleHumansHyaluronic AcidMiceNanoparticlesAntineoplastic AgentsArtesunateHyaluronic AcidIronMicellesnanomicellesnon‐Fentonoxidative stressreactive oxygen speciesself‐targeting

Identifiers

PMID38952042
PMCPMC11871113

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.