Observational studyOrthopaedic surgery2024
The Differences on the Fatty Infiltration of Paraspinal Muscles between Single- and Multiple-level Intervertebral Disc Degeneration in Patients with Lumbar Disc Herniation.
Observational study in Orthopaedic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Association Between Lumbar Disc Degeneration and Paraspinal Muscle Morphology: The Role of Age in a Quantitative Magnetic Resonance Imaging-Based Study.Biomedicines · 2026Article
- [Effectiveness analysis of single-incision treatment for adjacent two-segmental lumbar disc herniation using uni-portal non-coaxial spinal endoscopic surgery].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Association Between Degeneration of the Paraspinal Muscles and Nerve Root Compression in Lumbar Disc Herniation Patients Who Underwent Percutaneous Endoscopic Lumbar Discectomy.Orthopaedic surgery · 2026Article
- Automated deep-learning quantification of intramuscular fat in lumbar spine muscles on Dixon MRI: validation and normative reference values from 173 healthy adults.BMC medical imaging · 2026Article
- Comparative outcomes of arthroscopy-assisted uniportal spinal surgery vs. unilateral biportal endoscopy for adjacent two-segment lumbar disc herniation: a retrospective cohort study.Frontiers in surgery · 2026Article
- Association between lumbar disc degeneration at L4-L5 level and atrophy of paraspinal muscles and gluteus medius: a cross-sectional study using 3T quantitative magnetic resonance imaging.BMC medical imaging · 2025Article
- Multivariate Analysis of Risk Factors for Atlantoaxial Osteoarthritis: A Retrospective Cohort Study on Ligament Ossification, Joint Degeneration, and Muscle Fatty Infiltration.Orthopaedic surgery · 2025Article
- Comparative analysis of the correlation between paraspinal muscles fat infiltration and vertebral bone quality in patients with lumbar degenerative diseases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- The global burden of low back pain attributable high body mass index over the period 1990-2021 and projections up to 2035.Frontiers in nutrition · 2025Article
- Characteristic of Paraspinal Muscle Change in Coronal Sub-type of Degenerative Lumbar Scoliosis and its Potential Clinical Significance.Orthopaedic surgery · 2024Article
- The effect of aspirin on lumbar degeneration: an imaging-based study.Frontiers in surgery · 2024Article
- Efficacy of acupuncture for lumbar disc herniation: changes in paravertebral muscle and fat infiltration - a multicenter retrospective cohort study.Frontiers in endocrinology · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMultiple-level Intervertebral disc degeneration (IDD) in patients with lumbar disc herniation (LDH) is related to postoperative re-herniation and low back pain. Although many investigators believed that there is an interdependence between paraspinal muscles degeneration and IDD, few studies focused on the fatty infiltration of paraspinal muscles on single- and multiple-level IDD in patients with LDH. This study aims to investigate the difference on the fatty infiltration of paraspinal muscles between single- and multiple-levels IDD in patients with LDH. and to explore in patients with LDH whether fatty infiltration is a potential risk factor for multiple-level IDD.
methodsThis study was conducted as a retrospective observational analysis of 82 patients with LDH from January 1, 2020 to December 30, 2020 in our hospital were enrolled. Twenty-seven cases had single-level IDD (Group A), and 55 cases had multiple-level IDD (Group B). We measured the mean computed tomography (CT) density value of the paraspinal muscles, including multifidus (MF), erector spinae (ES) and psoas muscle (PM) at each disc from L1 to S1. Subgroups were set to further analyze the odds ratio (OR) of fatty infiltration of paraspinal muscles in different sex and BMI groups. We measured sagittal angles and analyzed the relationships between these angles and IDD. Finally, we use logistic regression, adjusted for other confounding factors, to investigate whether fatty infiltration is an independent risk factor for multi-level IDD.
resultsThe average age in multi-level IDD (51.40 ± 15.47 years) was significantly higher than single-level IDD (33.37 ± 7.10 years). The mean CT density value of MF, ES and PM in single-level IDD was significantly higher than multi-level IDD (all ps < 0.001). There was no significant difference of the mean value of angles between the two groups. No matter being fat (body mass index [BMI] > 24.0 kg/m
conclusionsIn patients with LDH, patients with multiple-level IDD have more severe fatty infiltration of MF and ES than those with single-level IDD. Fatty infiltration of MF and ES are independent risk factors for multiple-level IDD in LDH patients.
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