Evidence map›Paper›PMID 38951998›Full record

ArticleJournal of travel medicine2024

Epidemiology of travel-associated dengue from 2007 to 2022: A GeoSentinel analysis.

Alexandre Duvignaud, Rhett J Stoney, Kristina M Angelo, Lin H Chen, Paolo Cattaneo, Leonardo Motta, Federico G Gobbi, Emmanuel Bottieau, Daniel L Bourque, Corneliu P Popescu and 20 more

Abstract read
In one paragraph

Article in Journal of travel medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Dengue and severe dengue.Clinical microbiology reviews · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Susceptibility ofInsects · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Alexandre DuvignaudDepartment of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France.ORCID 0000-0001-7139-2687
Rhett J StoneyDivision of Global Migration Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-4538-1463
Kristina M AngeloDivision of Global Migration Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lin H ChenDivision of Infectious Diseases and Travel Medicine, Mount Auburn Hospital, Cambridge, MA, USA.
Paolo CattaneoDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Leonardo MottaDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Federico G GobbiDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
Emmanuel BottieauDepartment of Clinical Sciences, Institute of Tropical Medicine, 155 Nationalestraat, Antwerp 2000, Belgium.
Daniel L BourqueSection of Infectious Diseases, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0003-0846-6422
Corneliu P PopescuCarol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Hedvig GlansDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Hilmir AsgeirssonDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Ines Oliveira-SoutoVall d'Hebron-Drassanes International Health Unit, Infectious Diseases Department, Vall d'Hebron University Hospital, International Health Programme of Catalan Health Institute (PROSICS), Barcelona, Spain.
Stephen D VaughanDepartment of Medicine, Division of Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Bhawana AmatyaCIWEC Hospital and Travel Medicine Center, Lainchaur, Kathmandu, Nepal.ORCID 0000-0001-9888-4702
Francesca F NormanNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, CIBERINFEC, IRYCIS, Madrid, Spain.ORCID 0000-0003-0336-7767
Jesse WaggonerDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Marta Díaz-MenéndezTropical Medicine Department, Hospital Universitario La Paz-Carlos III, IdIPAz, and CIBERINFECT, Madrid, Spain.ORCID 0000-0002-9427-5237
Michael BeadsworthTropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
Silvia OdoliniUniversity Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.
Daniel Camprubí-FerrerISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0003-4215-6030
Loic EpelboinInfectious and Tropical Diseases Unit and CIC Inserm 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana.ORCID 0000-0002-3481-5991
Bradley A ConnorWeill Cornell Medical College and the New York Center for Travel and Tropical Medicine, New York, NY, USA.
Gilles EperonDivision of Tropical and Humanitarian Medicine, Geneva University Hospitals & Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-3371-4320
Eli SchwartzThe Center of Geographical Medicine and Tropical Diseases, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel.
Michael LibmanDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.ORCID 0000-0003-3416-6482
Denis MalvyDepartment of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France.
Davidson H HamerDepartment of Global Health, Boston University School of Public Health, Boston, MA, USA.
Ralph HuitsDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
GeoSentinel Network

Funding

GeoSentinel FoundationInternational Society of Travel Medicine 1 U01CK000632-01-00ISTMNCEZID CDC HHS U01 CK000632NCEZID CDC HHS U50 CK000189Public Health Agency of CanadaUS Centers for Disease Control and Prevention
6 · The paper itself

Abstract

backgroundDengue is a leading cause of febrile illness among international travellers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travellers evaluated at GeoSentinel sites from 2007 to 2022.

methodsWe retrieved GeoSentinel records of dengue among travellers residing in non-endemic countries. We considered dengue confirmed when diagnosed by a positive dengue virus (DENV)-specific reverse-transcriptase polymerase chain reaction, positive NS-1 antigen and/or anti-DENV IgG seroconversion, and probable when diagnosed by single anti-DENV IgM or high-titre anti-DENV IgG detection. Severe dengue was defined as evidence of clinically significant plasma leakage or bleeding, organ failure, or shock, according to the 2009 World Health Organization guidance. Complicated dengue was defined as either severe dengue or dengue with presence of any warning sign. Analyses were descriptive.

resultsThis analysis included 5958 travellers with confirmed (n = 4859; 81.6%) or probable (n = 1099; 18.4%) dengue. The median age was 33 years (range: <1-91); 3007 (50.5%) travellers were female. The median travel duration was 21 days (interquartile range [IQR]: 15-32). The median time between illness onset and GeoSentinel site visit was 7 days (IQR: 4-15). The most frequent reasons for travel were tourism (67.3%), visiting friends or relatives (12.2%) and business (11.0%). The most frequent regions of acquisition were South East Asia (50.4%), South Central Asia (14.9%), the Caribbean (10.9%) and South America (9.2%). Ninety-five (1.6%) travellers had complicated dengue, of whom 27 (0.5%) had severe dengue and one died. Of 2710 travellers with data available, 724 (26.7%) were hospitalized. The largest number of cases (n = 835) was reported in 2019.

conclusionsA broad range of international travellers should be aware of the risk of acquiring dengue and receive appropriate pre-travel counselling regarding preventive measures. Prospective cohort studies are needed to further elucidate dengue risk by destination and over time, as well as severe outcomes and prolonged morbidity (long dengue) due to travel-related dengue.

Indexed as

DengueDengue VirusTravelAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedSentinel SurveillanceTravel-Related IllnessAcute febrile illnessDengueEpidemiologySurveillanceTraveller

Identifiers

PMID38951998
PMCPMC11502266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.