Evidence map›Paper›PMID 38951902›Full record

ArticleBMC complementary medicine and therapies2024

Protocol for a pragmatic trial of Cannabidiol (CBD) to improve chronic pain symptoms among United States Veterans.

Rachel S Bergmans, Riley Wegryn-Jones, Catherine Klida, Vivian Kurtz, Laura Thomas, David A Williams, Daniel J Clauw, Kelley M Kidwell, Amy S B Bohnert, Kevin F Boehnke

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06213233 (Pragmatic Trial of Cannabidiol to Improve Chronic Pain Symptoms Among Veterans), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06213233 phase2recruitingnot on this map

Pragmatic Trial of Cannabidiol to Improve Chronic Pain Symptoms Among Veterans

TypeinterventionalSponsorKevin BoehnkeRan2024 to 2028Enrolled468ConditionsPain, ChronicArmsPlacebo, Cannabidiol
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Review
  4. The Pharmacology of Cannabinoids in Chronic Pain.Medical cannabis and cannabinoids
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rachel S BergmansMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA.ORCID http://orcid.org/0000-0001-5740-6691
Riley Wegryn-JonesMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA.ORCID http://orcid.org/0009-0006-4014-3462
Catherine KlidaMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA.
Vivian KurtzMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA.
Laura ThomasMedical School, Department of Anesthesiology, University of Michigan, Ann Arbor, USA.ORCID http://orcid.org/0009-0003-8400-1309
David A WilliamsMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA.ORCID http://orcid.org/0000-0002-5052-4895
Daniel J ClauwMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA.
Kelley M KidwellSchool of Public Health, Biostatistics, University of Michigan, Ann Arbor, USA.
Amy S B BohnertMedical School, Department of Anesthesiology, University of Michigan, Ann Arbor, USA.
Kevin F BoehnkeMedical School, Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA. kboehnke@med.umich.edu.ORCID http://orcid.org/0000-0003-3696-3979

Funding

Cannabinoid Effects on Sleep and Pain Mechanisms in Osteoarthritis of the KneeK01DA049219 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, KEVIN FOXMAN · 2020 to 2023
$569k
NIDA NIH HHS K01 DA049219State of Michigan Veteran Marijuana Research Grant Program VMR2022-03The National Institute of Arthritis and Musculoskeletal and Skin Diseases K01ADA049219
6 · The paper itself

Abstract

backgroundChronic pain affects over 100 million Americans, with a disproportionately high number being Veterans. Chronic pain is often difficult to treat and responds variably to medications, with many providing minimal relief or having adverse side effects that preclude use. Cannabidiol (CBD) has emerged as a potential treatment for chronic pain, yet research in this area remains limited, with few studies examining CBD's analgesic potential. Because Veterans have a high need for improved pain care, we designed a clinical trial to investigate CBD's effectiveness in managing chronic pain symptoms among Veterans. We aim to determine whether CBD oral solution compared to placebo study medication is associated with greater improvement in the Patient Global Impression of Change (PGIC).

methodsWe designed a randomized, double-blind, placebo-controlled, pragmatic clinical trial with 468 participants. Participants will be randomly assigned in a 1:1 ratio to receive either placebo or a CBD oral solution over a 4-week period. The trial is remote via a smartphone app and by shipping study materials, including study medication, to participants. We will compare the difference in PGIC between the CBD and placebo group after four weeks and impacts on secondary outcomes (e.g., pain severity, pain interference, anxiety, suicide ideation, and sleep disturbance). DISCUSSION: Once complete, this trial will be among the largest to date investigating the efficacy of CBD for chronic pain. Findings from this clinical trial will contribute to a greater knowledge of CBD's analgesic potential and guide further research. Given the relative availability of CBD, our findings will help elucidate the potential of an accessible option for helping to manage chronic pain among Veterans.

trial registrationThis protocol is registered at clinicaltrials.gov under study number NCT06213233.

Indexed as

CannabidiolChronic PainVeteransAdultAnalgesicsDouble-Blind MethodFemaleHumansMaleMiddle AgedPragmatic Clinical Trials as TopicUnited StatesAnalgesicsCannabidiolAnalgesicCannabinoidsCannabisClinical TrialCommunity-engaged researchMarijuanaPainRandomized Controlled TrialVeteran health

Identifiers

PMID38951902
PMCPMC11218053

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.