Evidence map›Paper›PMID 38951854›Full record

ArticleBMC oral health2024

A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus.

Hala H Hazzaa, Marwa A M El Shiekh, Osama Elkashty, Eman Magdy, Dalia Riad, Eman Khalifa, Gasser M Elewa, Naglaa M Kamal

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hala H HazzaaDepartment of Oral Medicine, Periodontology and Diagnosis, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-9320-295X
Marwa A M El ShiekhOral and Dental Biology Department, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.ORCID http://orcid.org/0000-0003-0655-3354
Osama ElkashtyDepartment of Oral Pathology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.ORCID http://orcid.org/0000-0002-4875-7534
Eman MagdyDepartment of Oral Medicine, Diagnosis and Periodontology, Faculty of Dentistry, Beni_Suef University, Maadi, Cairo, Egypt. emanmagdy@dent.bsu.edu.eg.ORCID http://orcid.org/0000-0002-0134-1582
Dalia RiadDepartment of Oral Biology, Faculty of Dentistry, Beni_Suef University, Maadi, Cairo, Egypt.ORCID http://orcid.org/0000-0001-7829-6452
Eman KhalifaDepartment of Cell Biology, Faculty of Oral and Dental Medicine, Delta University for Science & Technology, Dakhliya, Egypt.ORCID http://orcid.org/0000-0003-1029-9571
Gasser M ElewaDepartment of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Delta University for Science and Technology, Dakahlia, Egypt.ORCID http://orcid.org/0000-0002-7435-6574
Naglaa M KamalDepartment of Oral Pathology, Faculty of Oral and Dental Medicine, Ahram Canadian University, 6th of October, Cairo, Egypt.ORCID http://orcid.org/0000-0002-3950-3962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOral lichen planus carries a risk for malignancy. The pathogenesis of the disease is mediated by various inflammatory mediators. Several mediators could be responsible for the oncogenic behavior in certain cases. Hypoxia-inducible factor-1a (HIF-1), and its possible correlation to Galactin-3 (Gal-3) and matrix metalloproteinase-9 (MMP-9) over expression represents an important indicator for malignant transformation. The investigation of these factors may present evidence-based information on malignant transformation of the disease. SUBJECTS AND

methodsThe study investigated the expression of HIF-1, Gla-3 and MMP-9 in tissue samples of OLP compared to control subjects of un-inflamed gingival overgrowth. 20 biospecimen were allocated in each group.

resultsImmunohistochemical findings of OLP showed immunoreactivity for Galectin 3, HIF1a and MMP-9 by most of the epithelial cells. There was a positive correlation between HIF1α and MMP-9, r = 0.9301 (P-value < 0.00001). A positive correlation was detected between Galectin 3 and MMP-9, r = 0.7292 (P-value = 0.000264) between Galectin 3 and HIF1α, r = 0.5893 (P-value = 0.006252).

conclusionThese findings confirm the hypothesis that the adaptive pathways to hypoxia as Gal 3 and MMP-9 expressions and their HIF-1 may play a crucial role in carcinogenesis of OLP.

Indexed as

Galectin 3Hypoxia-Inducible Factor 1, alpha SubunitLichen Planus, OralMatrix Metalloproteinase 9AdultBlood ProteinsCase-Control StudiesCell Transformation, NeoplasticEpithelial CellsFemaleGalectinsHumansImmunohistochemistryMaleMiddle AgedBlood ProteinsGalectin 3GalectinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitLGALS3 protein, humanMatrix Metalloproteinase 9MMP9 protein, humanGalactin-3Hypoxia-inducible factor 1aMMP-9Oral lichen planus

Identifiers

PMID38951854
PMCPMC11218350

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