Evidence map›Paper›PMID 38951848›Full record

ArticleBMC infectious diseases2024

Differences in virus and immune dynamics for SARS-CoV-2 Delta and Omicron infections by age and vaccination histories.

Maxine W Tan, Anet J N Anelone, An Ting Tay, Ren Ying Tan, Kangwei Zeng, Kelvin Bryan Tan, Hannah Eleanor Clapham

Abstract read
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maxine W TanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. maxine@u.nus.edu.
Anet J N AneloneSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
An Ting Tay *Ministry of Health, Singapore, Singapore.
Ren Ying Tan *Ministry of Health, Singapore, Singapore.
Kangwei Zeng *Ministry of Health, Singapore, Singapore.
Kelvin Bryan TanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Hannah Eleanor ClaphamSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Funding

Ministry of Education - Singapore Academic Research Fund Tier 1 (FY2020)
6 · The paper itself

Abstract

Vaccination against COVID-19 was integral to controlling the pandemic that persisted with the continuous emergence of SARS-CoV-2 variants. Using a mathematical model describing SARS-CoV-2 within-host infection dynamics, we estimate differences in virus and immunity due to factors of infecting variant, age, and vaccination history (vaccination brand, number of doses and time since vaccination). We fit our model in a Bayesian framework to upper respiratory tract viral load measurements obtained from cases of Delta and Omicron infections in Singapore, of whom the majority only had one nasopharyngeal swab measurement. With this dataset, we are able to recreate similar trends in URT virus dynamics observed in past within-host modelling studies fitted to longitudinal patient data.We found that Omicron had higher R

Indexed as

COVID-19COVID-19 VaccinesSARS-CoV-2VaccinationAdolescentAdultAgedAged, 80 and overAge FactorsBayes TheoremFemaleHumansMaleMiddle AgedModels, TheoreticalSingaporeCOVID-19 VaccinesAgeBayesian inferenceImmunityMechanistic modelModellingSARS-Cov-2VaccinationVariantsWaningWithin-host

Identifiers

PMID38951848
PMCPMC11218222

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.