Evidence map›Paper›PMID 38951803›Full record

ArticleBMC cancer2024

Enhancing circulatory myokines and extracellular vesicle uptake with targeted exercise in patients with prostate cancer (the MYEX trial): a single-group crossover study.

Jin-Soo Kim, Dennis R Taaffe, Daniel A Galvão, Timothy D Clay, Andrew D Redfern, Elin S Gray, Robert U Newton

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02730338 (INTense ExeRcise for SurviVAL Among Men with Metastatic Prostate Cancer), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02730338 naactive not recruitingnot on this map

INTense ExeRcise for SurviVAL Among Men with Metastatic Prostate Cancer (INTERVAL - GAP4): a Multicentre, Randomised, Controlled, Phase III Study

TypeinterventionalSponsorMovember FoundationRan2016 to 2026Enrolled866ConditionsMetastatic Prostate CancerArmsHigh intensity aerobic and resistance training, Psychosocial support
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jin-Soo KimExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Timothy D ClayExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Andrew D RedfernDepartment of Medical Oncology, Fiona Stanley Hospital, Murdoch, WA, Australia.
Elin S GraySchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia. r.newton@ecu.edu.au.

Funding

World Cancer Research Fund PFG_FULL_2023_009
6 · The paper itself

Abstract

introductionPhysical activity is associated with improved disease progression and cancer-specific survival in patients with prostate cancer (PCa). However, the mechanisms underlying these associations remain unclear, while the relative impact of exercise modes is unknown. This study aims to examine the differential impact of exercise mode on tumour-suppressive skeletal muscle-associated systemic molecules as well as their delivery mechanism. This study will compare the effects of the two main exercise modes, aerobic and resistance, on (1) circulatory myokine levels, (2) skeletal muscle-induced extracellular vesicle abundance and cargo contents, and (3) uptake of extracellular vesicles (EVs) in PCa cells in patients with localised or advanced PCa.

methodsA single-group cross-over design will be used for patients at opposite ends of the disease spectrum. A total of 32 patients (localised PCa, n = 16; metastatic castrate-resistant PCa, n = 16) will be recruited while capitalising on two ongoing studies. Ethics amendment has been approved for two ongoing trials to share data, implement the acute exercise sessions, and collect additional blood samples from patients. The patients will undertake two exercise sessions (aerobic only and resistance only) in random order one week apart. Blood will be collected before, after, and 30 min post-exercise. Circulating/EV-contained myokine levels (irisin, IL-6, IL-15, FGF-21, and SPARC) and plasma skeletal muscle-induced EVs will be measured using ELISA and flow cytometry. PCa cell line growth with or without collected plasma will be examined using PCa cell lines (LNCaP, DU-145, and PC-3), while evaluating cellular uptake of EVs. Ethics amendments have been approved for two capitalising studies to share data, implement acute exercise sessions and collect additional samples from the patients. DISCUSSION: If findings show a differential impact of exercise mode on the establishment of an anti-cancer systemic environment, this will provide fundamental knowledge for developing targeted exercise prescriptions for patients with PCa across different disease stages. Findings will be reported in peer-reviewed publications and scientific conferences, in addition to working with national support groups to translate findings for the broader community.

trial registrationThe registration for the two capitalising studies are NCT02730338 and ACTRN12618000225213.

Indexed as

Cross-Over StudiesExerciseExtracellular VesiclesMyokinesProstatic NeoplasmsAgedClinical Studies as TopicExercise TherapyHumansMaleMiddle AgedMuscle, SkeletalMyokinesExerciseExtracellular vesiclesMyokinesProstate cancer

Identifiers

PMID38951803
PMCPMC11218391

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.