Evidence map›Paper›PMID 38951761›Full record

ArticleBMC neurology2024

Comparison between MRI-negative and positive results and the predictors for a poor prognosis in patients with idiopathic acute transverse myelitis.

Yu Zhou, Qianxi Chen, Weiming Gan, Xiuwen Lin, Bo Wang, Meihong Zhou, Xiaomu Wu, Daojun Hong, Hao Chen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Journal of neurology · 2026
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yu Zhou *Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Qianxi Chen *Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Weiming GanDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Xiuwen LinDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Bo WangDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Meihong ZhouDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Xiaomu WuDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Daojun HongDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China. hongdaojun@hotmail.com.
Hao ChenDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China. 15179132576@163.com.

Funding

Double thousand talents program of Jiangxi province jxsq2019101021Jiangxi Science and Technology Project of Chinese medicine 2021B660National Natural Science Foundation of China 82101419Natural Science Foundation of Jiangxi Province 20212BAB216024
6 · The paper itself

Abstract

backgroundIdiopathic acute transverse myelitis (IATM) is a focal inflammatory disorder of the spinal cord that results in motor, sensory, and autonomic dysfunction. However, the comparative analysis of MRI-negative and MRI-positive in IATM patients were rarely reported.

objectivesThe purpose of this study was to compare MRI-negative with MRI-positive groups in IATM patients, analyze the predictors for a poor prognosis, thus explore the relationship between MRI-negative and prognosis.

methodsWe selected 132 patients with first-attack IATM at the First Affiliated Hospital of Nanchang University from May 2018 to May 2022. Patients were divided into MRI-positive and MRI-negative group according to whether there were responsible spinal MRI lesions, and good prognosis and poor prognosis based on whether the EDSS score ≥ 4 at follow-up. The predictive factors of poor prognosis in IATM patients was analyzed by logistic regression models.

resultsOf the 132 patients, 107 first-attack patients who fulfilled the criteria for IATM were included in the study. We showed that 43 (40%) patients had a negative spinal cord MRI, while 27 (25%) patients were identified as having a poor prognosis (EDSS score at follow-up ≥ 4). Compared with MRI-negative patients, the MRI-positive group was more likely to have back/neck pain, spinal cord shock and poor prognosis, and the EDSS score at follow-up was higher. We also identified three risk factors for a poor outcome: absence of second-line therapies, high EDSS score at nadir and a positive MRI result.

conclusionsCompared with MRI-negative group, MRI-positive patients were more likely to have back/neck pain, spinal cord shock and poor prognosis, with a higher EDSS score at follow-up. The absence of second-line therapies, high EDSS score at nadir, and a positive MRI were risk factors for poor outcomes in patients with first-attack IATM. MRI-negative patients may have better prognosis, an active second-line immunotherapy for IATM patients may improve clinical outcome.

Indexed as

Magnetic Resonance ImagingMyelitis, TransverseAdultFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSpinal CordIdiopathic acute transverse myelitisMRI-negativePoor outcomePredictive factors

Identifiers

PMID38951761
PMCPMC11218061

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