ArticleNature medicine2024
Continuous neural control of a bionic limb restores biomimetic gait after amputation.
Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Neural Interfaces for Bidirectional Sensory Restoration in Limb Prostheses: Current Evidence and Clinical Translation.Journal of clinical medicine · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Phase-Based Haptic Feedback for Improved Neural Control of a Robotic Prosthetic Ankle: A Preliminary Study.IEEE robotics and automation letters · 2026Article
- Embroidered textile sensors for real-time multiaxial force mapping in prosthetics.Science advances · 2026Article
- Bio-Inspired Gaze and Neural Command Fusion for Assistive Smartphone Interaction.Biomimetics (Basel, Switzerland) · 2026Article
- Human Implementation of Upper Extremity Amputation Incorporating Agonist-Antagonist Myoneural Interface Construction.Plastic and reconstructive surgery · 2026Article
- A myoneural actuator with engineered biophysics for implantable biohybrid systems.Nature communications · 2026Article
- Design and evaluation of a bone-anchored, neurally-controlled knee prosthesis.Journal of neuroengineering and rehabilitation · 2026Article
- Mechanomedicine.Nature reviews bioengineering · 2026Article
- Ongoing Clinical Challenges in Nerve Surgery (Nerve SPACE 2025).Journal of hand surgery global online · 2026Article
- Decoding phantom limb movements from intraneural recordings.Nature communications · 2026Article
- A Bioinspired Perceptual Sensor for Spatiotemporal Decoding of Haptic and Pain Stimuli in Prostheses.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Article
- Using EMG Biofeedback to Restore Closed-Loop Neural Control on a Powered Prosthetic Ankle.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Wearable technologies for assisted mobility in the real world.Nature communications · 2025Review
- Real-time image-guided and computer augmented reality in minimally invasive hepatopancreatobiliary surgery cutting edge technology transforming HPB surgery.Surgical endoscopy · 2025Review
- Toward Natural Limb Function: A New Era in Prosthetic Innovation.Annals of neurology · 2025Review
- Artificial Nervous Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Progress, challenges and future of linguistic neural decoding with deep learning.Communications biology · 2025Review
- Repair, Regeneration, and Replacement, Revisited (Redux).Journal of diabetes science and technology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
For centuries scientists and technologists have sought artificial leg replacements that fully capture the versatility of their intact biological counterparts. However, biological gait requires coordinated volitional and reflexive motor control by complex afferent and efferent neural interplay, making its neuroprosthetic emulation challenging after limb amputation. Here we hypothesize that continuous neural control of a bionic limb can restore biomimetic gait after below-knee amputation when residual muscle afferents are augmented. To test this hypothesis, we present a neuroprosthetic interface consisting of surgically connected, agonist-antagonist muscles including muscle-sensing electrodes. In a cohort of seven leg amputees, the interface is shown to augment residual muscle afferents by 18% of biologically intact values. Compared with a matched amputee cohort without the afferent augmentation, the maximum neuroprosthetic walking speed is increased by 41%, enabling equivalent peak speeds to persons without leg amputation. Further, this level of afferent augmentation enables biomimetic adaptation to various walking speeds and real-world environments, including slopes, stairs and obstructed pathways. Our results suggest that even a small augmentation of residual muscle afferents restores biomimetic gait under continuous neuromodulation in individuals with leg amputation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.