Evidence map›Paper›PMID 38951610›Full record

ArticleThe EMBO journal2024

YTHDC1 m

Daniel Elvira-Blázquez, José Miguel Fernández-Justel, Aida Arcas, Luisa Statello, Enrique Goñi, Jovanna González, Benedetta Ricci, Sara Zaccara, Ivan Raimondi, Maite Huarte

Abstract read
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. mFrontiers in cell and developmental biology · 2026
    Review
  6. Article
  7. Review
  8. Decoding the role of mNeurochemistry international · 2025
    Review
  9. METTL3-mediated mMolecular biology reports · 2025
    Review
  10. Review
  11. De novo assembly of RNA mCell reports · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel Elvira-BlázquezCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-2229-6549
José Miguel Fernández-JustelCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-7153-067X
Aida ArcasCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0001-9182-0810
Luisa StatelloCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0001-8261-4214
Enrique GoñiCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Jovanna GonzálezCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Benedetta RicciDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5213-0531
Sara ZaccaraDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6569-2015
Ivan RaimondiNew York Genome Center, New York, NY, USA. iraimondi@nygenome.org.ORCID http://orcid.org/0000-0002-9522-2794
Maite HuarteCenter for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. maitehuarte@unav.es.ORCID http://orcid.org/0000-0003-3753-6493

Funding

The DF phospho-code regulating the degradation of m6A mRNAK22CA258954 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZACCARA, SARA · 2022 to 2024
$577k
EC | European Research Council (ERC) ERC Consolidator grant 771425Ministerio de Ciencia e Innovación (MCIN) BFU2017-82773-PMinisterio de Ciencia e Innovación (MCIN) PRE2018-085992NCI NIH HHS K22 CA258954Worldwide Cancer Research (WCR) 20-0204
6 · The paper itself

Abstract

Cells have evolved a robust and highly regulated DNA damage response to preserve their genomic integrity. Although increasing evidence highlights the relevance of RNA regulation, our understanding of its impact on a fully efficient DNA damage response remains limited. Here, through a targeted CRISPR-knockout screen, we identify RNA-binding proteins and modifiers that participate in the p53 response. Among the top hits, we find the m

Indexed as

DNA DamageTumor Suppressor Protein p53AdenosineCell ProliferationGene Expression RegulationGenomic InstabilityHumansNerve Tissue ProteinsRNA-Binding ProteinsRNA Splicing FactorsAdenosineNerve Tissue ProteinsN-methyladenosineRNA-Binding ProteinsRNA Splicing FactorsTP53 protein, humanTumor Suppressor Protein p53YTHDC1 protein, humanDDRp53RNAPII PausingSplicingYTHDC1

Identifiers

PMID38951610
PMCPMC11329685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.